ArticleBioMed research international2015
How to Quantify Penile Corpus Cavernosum Structures with Histomorphometry: Comparison of Two Methods.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Immediate and late effects of supraphysiological doses of nandrolone decanoate on the testis of rats.Acta cirurgica brasileira · 2025Article
- Impact of maternal stress on metabolism and penile morphology in young offspring rats.Histology and histopathology · 2024Article
- Article
- Effects of chronic restraint stress in the prostate of prepubertal and adult rats.Acta cirurgica brasileira · 2023Article
- Effects of Vitamin D Restricted Diet Administered during Perinatal and Postnatal Periods on the Penis of Wistar Rats.BioMed research international · 2018Article
- Testosterone replacement maintains smooth muscle content in the corpus cavernosum of orchiectomized rats.Asian journal of urology · 2017Article
- Effect of tamoxifen on fibrosis, collagen content and transforming growth factor-β1, -β2 and -β3 expression in common bile duct anastomosis of pigs.International journal of experimental pathology · 2017Article
- Effects of dutasteride and tamsulosin on penile morphology in a rodent model.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Effect of a high-fat diet on the rat bladder wall and bioactive action of Brazil nut oil.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- The prostate after castration and hormone replacement in a rat model: structural and ultrastructural analysis.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The use of morphometrical tools in biomedical research permits the accurate comparison of specimens subjected to different conditions, and the surface density of structures is commonly used for this purpose. The traditional point-counting method is reliable but time-consuming, with computer-aided methods being proposed as an alternative. The aim of this study was to compare the surface density data of penile corpus cavernosum trabecular smooth muscle in different groups of rats, measured by two observers using the point-counting or color-based segmentation method. Ten normotensive and 10 hypertensive male rats were used in this study. Rat penises were processed to obtain smooth muscle immunostained histological slices and photomicrographs captured for analysis. The smooth muscle surface density was measured in both groups by two different observers by the point-counting method and by the color-based segmentation method. Hypertensive rats showed an increase in smooth muscle surface density by the two methods, and no difference was found between the results of the two observers. However, surface density values were higher by the point-counting method. The use of either method did not influence the final interpretation of the results, and both proved to have adequate reproducibility. However, as differences were found between the two methods, results obtained by either method should not be compared.
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