Evidence map›Paper›PMID 26413500›Full record

Trial reportBioMed research international2015

The Effect of Omega-3 Docosahexaenoic Acid Supplementation on Gestational Length: Randomized Trial of Supplementation Compared to Nutrition Education for Increasing n-3 Intake from Foods.

Mary A Harris, Melanie S Reece, James A McGregor, John W Wilson, Shannon M Burke, Marsha Wheeler, Jennifer E Anderson, Garry W Auld, Janice I French, Kenneth G D Allen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018
    Pooled it
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Reference Range of Plasma Fatty Acids in North Indian Pregnant Population.Indian journal of clinical biochemistry : IJCB · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary A HarrisDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Melanie S ReeceDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA ; Department of Neonatology, University of Colorado Hospital, Denver, CO 80045, USA.
James A McGregorDepartment of Obstetrics and Gynecology, Denver Health Medical Center, Denver, CO 80237, USA.
John W WilsonDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Shannon M BurkeDepartment of Obstetrics and Gynecology, Denver Health Medical Center, Denver, CO 80237, USA ; Department of Obstetrics and Gynecology, University of Colorado Hospital, Denver, CO 80045, USA.
Marsha WheelerDepartment of Obstetrics and Gynecology, University of Colorado Hospital, Denver, CO 80045, USA.
Jennifer E AndersonDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Garry W AuldDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Janice I FrenchLA Best Babies Network, Los Angeles, CA 90015, USA.
Kenneth G D AllenDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDHA supplementation was compared to nutrition education to increase DHA consumption from fish and DHA fortified foods.

designThis two-part intervention included a randomized double-blind placebo controlled DHA supplementation arm and a nutrition education arm designed to increase intake of DHA from dietary sources by 300 mg per day.

settingDenver Health Hospitals and Clinics, Denver, Colorado, USA. POPULATION: 871 pregnant women aged 18-40 were recruited between 16 and 20 weeks of gestation of whom 564 completed the study and complete delivery data was available in 505 women and infants.

methodsSubjects received either 300 or 600 mg DHA or olive oil placebo or nutrition education. MAIN OUTCOME VARIABLE: Gestational length.

resultsGestational length was significantly increased by 4.0-4.5 days in women supplemented with 600 mg DHA per day or provided with nutrition education. Each 1% increase in RBC DHA at delivery was associated with a 1.6-day increase in gestational length. No significant effects on birth weight, birth length, or head circumference were demonstrated. The rate of early preterm birth (1.7%) in those supplemented with DHA (combined 300 and 600 mg/day) was significantly lower than in controls.

conclusionNutrition education or supplementation with DHA can be effective in increasing gestational length.

Indexed as

AdultBirth WeightBody HeightDietDietary SupplementsDocosahexaenoic AcidsFemaleHealth EducationHumansInfant, NewbornPregnancyPrenatal CareYoung AdultDocosahexaenoic Acids

Identifiers

PMID26413500
PMCPMC4564584

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.