ArticleGenomics data2015
Transcriptome profiling of sleeping, waking, and sleep deprived adult heterozygous Aldh1L1 - eGFP-L10a mice.
Article in Genomics data, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Sleep loss induces cholesterol-associated myelin dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Are there roles for heterogeneous ribosomes during sleep in the rodent brain?Frontiers in molecular biosciences · 2022Article
- Review
- Astroglial Calcium Signaling Encodes Sleep Need in Drosophila.Current biology : CB · 2021Article
- Sleep Disruption Exacerbates and Prolongs the Inflammatory Response to Traumatic Brain Injury.Journal of neurotrauma · 2020Article
- Review
- Glial phagocytic clearance in Parkinson's disease.Molecular neurodegeneration · 2019Review
- Astrocytes and the modulation of sleep.Current opinion in neurobiology · 2017Review
- Linking Network Activity to Synaptic Plasticity during Sleep: Hypotheses and Recent Data.Frontiers in neural circuits · 2017Review
- The Conscious Nematode: Exploring Hallmarks of Minimal Phenomenal Consciousness inInternational journal of psychological researchArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Transcriptomic studies revealed that hundreds of mRNAs show differential expression in the brains of sleeping relative to awake rats, mice, flies, and sparrows. Although these results have offered clues regarding the molecular consequences of sleep and sleep loss, their functional significance thus far has been limited. This is probably because the previous studies pooled transcripts from all brain cells, including neurons and glia. In Bellesi et al. 2015 [1], we used the translating ribosome affinity purification technology (TRAP) and microarray analysis to obtain a genome-wide mRNA profiling of astrocytes as a function of sleep and wake. We used bacterial artificial chromosome (BAC) transgenic mice expressing eGFP tagged ribosomal protein L10a under the promoter of the Aldh1L1 gene, a highly expressed astrocytic gene. Using this approach, we could extract only the astrocytic mRNAs, and only those already committed to be translated into proteins (L10a is part of the translational machinery). Here, we report a detailed description of the protocol used in the study [1]. Array data have been submitted to NCBI GEO under accession number (GSE69079).
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Registered trials
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