ReviewSpermatogenesis
Disruption of estrogen receptor signaling and similar pathways in the efferent ductules and initial segment of the epididymis.
Review in Spermatogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Primary and motile cilia in the efferent ductules: a role for IFT88 in maintaining male fertility.Cellular and molecular life sciences : CMLS · 2026Article
- A Review on the Effects of Atrazine on Male Rat Reproductive System Cytoarchitecture, Steroidogenesis and Oxidative Pathway.Journal of molecular histology · 2026Review
- Histology and mRNA expression of unilateral testicular atrophy in three immunocastrated boars: a case report.BMC veterinary research · 2026Article
- ARL13B controls male reproductive tract physiology through primary and Motile Cilia.Communications biology · 2024Article
- Male animal sterilization: history, current practices, and potential methods for replacing castration.Frontiers in veterinary science · 2024Review
- Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†.Biology of reproduction · 2023Article
- Expression patterns of sex steroid receptors in developing mesonephros of the male mouse: three-dimensional analysis.Cell and tissue research · 2023Article
- Article
- The Mechanism and Experimental Validation of Forsythoside A in the Treatment of Male Infertility Were Analyzed Based on Network Pharmacology and Molecular Docking.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Morphological and morphometric changes and epithelial apoptosis are induced in the rat epididymis by long-term letrozole treatment.European journal of histochemistry : EJH · 2021Article
- Exogenous Factors Affecting the Functional Integrity of Male Reproduction.Life (Basel, Switzerland) · 2021Review
- Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system.Molecular human reproduction · 2021Article
- Motile cilia of the male reproductive system require miR-34/miR-449 for development and function to generate luminal turbulence.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Leukemia Inhibitory Factor-Receptor is Dispensable for Prenatal Testis Development but is Required in Sertoli cells for Normal Spermatogenesis in Mice.Scientific reports · 2018Article
- Estrogen in the male: a historical perspective.Biology of reproduction · 2018Review
- Estrogens in Male Physiology.Physiological reviews · 2017Review
- Membrane estrogen receptor 1 is required for normal reproduction in male and female mice.Journal of endocrinology and reproduction : JER · 2017Article
- Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice.PLoS genetics · 2017Article
- Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice.Endocrinology · 2016Article
- E2f4 and E2f5 are essential for the development of the male reproductive system.Cell cycle (Georgetown, Tex.) · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seminiferous tubular atrophy may involve indirectly the disruption of estrogen receptor-α (ESR1) function in efferent ductules of the testis. ESR1 helps to maintain fluid resorption by the ductal epithelium and the inhibition or stimulation of this activity in rodent species will lead to fluid accumulation in the lumen. If not resolved, the abnormal buildup of fluid in the head of the epididymis and efferent ductules becomes a serious problem for the testis, as it leads to an increase in testis weight, tubular dilation and seminiferous epithelial degeneration, as well as testicular atrophy. The same sequence of pathogenesis occurs if the efferent ductule lumen becomes occluded. This review provides an introduction to the role of estrogen in the male reproductive tract but focuses on the various overlapping mechanisms that could induce efferent ductule dysfunction and fluid backpressure histopathology. Although efferent ductules are difficult to find, their inclusion in routine histological evaluations is recommended, as morphological images of these delicate tubules may be essential for understanding the mechanism of testicular injury, especially if dilations are observed in the rete testis and/or seminiferous tubules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.