ArticleThe annals of applied statistics
BAYESIAN METHODS FOR GENETIC ASSOCIATION ANALYSIS WITH HETEROGENEOUS SUBGROUPS: FROM META-ANALYSES TO GENE-ENVIRONMENT INTERACTIONS.
Article in The annals of applied statistics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.Nature communications · 2025Pooled it
- An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations.PLoS genetics · 2018Pooled it
- Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.American journal of human genetics · 2015Pooled it
- Bayesian test for colocalisation between pairs of genetic association studies using summary statistics.PLoS genetics · 2014Pooled it
- Diagnosing scientific replicability through probabilistic distinguishability.Bioinformatics (Oxford, England) · 2026Article
- Article
- GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.medRxiv : the preprint server for health sciences · 2023Article
- The Bayesian lens and Bayesian blinkers.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2023Review
- CLIMB: High-dimensional association detection in large scale genomic data.Nature communications · 2022Article
- Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide.HGG advances · 2022Article
- Model-based assessment of replicability for genome-wide association meta-analysis.Nature communications · 2021Article
- A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits.American journal of human genetics · 2020Article
- Social affiliation predicts mitochondrial DNA copy number in female rhesus macaques.Biology letters · 2019Article
- Meta-Analysis of SNP-Environment Interaction With Overlapping Data.Frontiers in genetics · 2019Article
- A Bayesian framework for multiple trait colocalization from summary association statistics.Bioinformatics (Oxford, England) · 2018Article
- A Scalable Bayesian Method for Integrating Functional Information in Genome-wide Association Studies.American journal of human genetics · 2017Article
- Bayesian genome- and epigenome-wide association studies with gene level dependence.Biometrics · 2017Article
- BAYESIAN LARGE-SCALE MULTIPLE REGRESSION WITH SUMMARY STATISTICS FROM GENOME-WIDE ASSOCIATION STUDIES.The annals of applied statistics · 2017Article
- Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.PLoS genetics · 2017Article
- High-throughput allele-specific expression across 250 environmental conditions.Genome research · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Genetic association analyses often involve data from multiple potentially-heterogeneous subgroups. The expected amount of heterogeneity can vary from modest (e.g. a typical meta-analysis), to large (e.g. a strong gene-environment interaction). However, existing statistical tools are limited in their ability to address such heterogeneity. Indeed, most genetic association meta-analyses use a "fixed effects" analysis, which assumes no heterogeneity. Here we develop and apply Bayesian association methods to address this problem. These methods are easy to apply (in the simplest case, requiring only a point estimate for the genetic effect, and its standard error, from each subgroup), and effectively include standard frequentist meta-analysis methods, including the usual "fixed effects" analysis, as special cases. We apply these tools to two large genetic association studies: one a meta-analysis of genome-wide association studies from the Global Lipids consortium, and the second a cross-population analysis for expression quantitative trait loci (eQTLs). In the Global Lipids data we find, perhaps surprisingly, that effects are generally quite homogeneous across studies. In the eQTL study we find that eQTLs are generally shared among different continental groups, and discuss consequences of this for study design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.