Evidence map›Paper›PMID 26413057›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli.

Franciane Gomig, Carolina Weigert Galvão, Denis Leandro de Freitas, Larissa Labas, Rafael Mazer Etto, Luiz Antonio Esmerino, Marcelo Andrade de Lima, Marcia Helena Appel, Silvio Marques Zanata, Maria Berenice Reynaud Steffens and 2 more

Open access · hybridAbstract read
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In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Franciane GomigDepartamento de Biologia Estrutural, Molecular e Genética, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil .
Carolina Weigert GalvãoDepartamento de Biologia Estrutural, Molecular e Genética, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil .
Denis Leandro de FreitasDepartamento de Biologia Estrutural, Molecular e Genética, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil .
Larissa LabasDepartamento de Biologia Estrutural, Molecular e Genética, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil .
Rafael Mazer EttoDepartamento de Química, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil .
Luiz Antonio EsmerinoDepartamento de Análises Clínicas, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil .
Marcelo Andrade de LimaDepartamento de Bioquímica, Universidade Federal de São Paulo, São Paulo, SP, Brazil .
Marcia Helena AppelDepartamento de Biologia Estrutural, Molecular e Genética, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil .
Silvio Marques ZanataDepartamento de Patologia Básica, Universidade Federal do Paraná, Curitiba, PR, Brazil .
Maria Berenice Reynaud SteffensDepartamento de Bioquímica, Universidade Federal do Paraná, Curitiba, PR, Brazil .
Helena Bonciani NaderDepartamento de Bioquímica, Universidade Federal de São Paulo, São Paulo, SP, Brazil .
Rafael Bertoni da SilveiraDepartamento de Biologia Estrutural, Molecular e Genética, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil .
Universidade Federal de São Paulo · BRUniversidade Federal do Paraná · BRUniversidade Estadual de Ponta Grossa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential relationship between biochemical characteristics and quinolone resistance in uropathogenic E. coli strains. The present work analyzed the quinolone sensitivity and biochemical activities of fifty-eight lactose-negative uropathogenic E. coli strains. A high percentage of the isolates (48.3%) was found to be resistant to at least one of the tested quinolones, and DNA sequencing revealed quinolone resistant determining region gyrA and parC mutations in the multi-resistant isolates. Statistical analyses suggested that the lack of ornithine decarboxylase (ODC) activity is correlated with quinolone resistance. Despite the low number of isolates examined, this is the first study correlating these characteristics in lactose-negative E. coli isolates.

Indexed as

Anti-Bacterial AgentsBrazilDecarboxylationDNA GyraseDNA Topoisomerase IVDrug Resistance, Multiple, BacterialEscherichia coli InfectionsFluoroquinolonesHumansLactoseMicrobial Sensitivity TestsNalidixic AcidOrnithineOrnithine DecarboxylaseUrinary Tract InfectionsUropathogenic Escherichia coliAnti-Bacterial AgentsDNA GyraseDNA Topoisomerase IVFluoroquinolonesLactoseNalidixic AcidOrnithineOrnithine DecarboxylasegyrAODCparCuropathogenic

Identifiers

PMID26413057
PMCPMC4568878
OpenAlexW1603791918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.