Evidence map›Paper›PMID 26412454›Full record

ArticleScientific reports2015

Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells.

Zhu Xishan, Zhang Bin, Zhao Haiyue, Dou Xiaowei, Bai Jingwen, Zhang Guojun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhu XishanThe Breast Center, Cancer Hospital, Shantou University Medical College, Shantou, China.
Zhang BinInstitute of Basic medicine. Peking Union Medical College, Chinese Academy of Medical Science, China.
Zhao HaiyueClinical department, Capital Medical University.
Dou XiaoweiThe Breast Center, Cancer Hospital, Shantou University Medical College, Shantou, China.
Bai JingwenThe Breast Center, Cancer Hospital, Shantou University Medical College, Shantou, China.
Zhang GuojunThe Breast Center, Cancer Hospital, Shantou University Medical College, Shantou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose derived Mesenchymal stem cells (AMSCs) are able to expand in vitro and undergo differentiation into multiple cell lineages, yet have low immunogenicity while exhibiting several immunoregulatory characteristics. We sought to investigate the immunomodulatory mechanisms of AMSCs to better understand their immunogenic properties. Following 10 days of chondrogenic differentiation or 48 hours of IFN-γ pretreatment, AMSCs retained low level immunogenicity but prominent immunoregulatory activity and AMSC immunogenicity was enhanced by chondrogenic differentiation or IFN-γ treatment. We found Jagged-2 expression was significantly elevated following chondrogenic differentiation or IFN-γ pretreatment. Jagged-2-RNA interference experiments suggested that Jagged-2-siRNA2 suppresses Jagged-2 expression during chondrogenic differentiation and in IFN-γ pretreated AMSCs. Besides, Jagged-2 interference attenuated immunosuppressive activity by mixed lymphocyte culture and mitogen stimulation experiments. So, the immunoregulatory activity of AMSCs, to some extent dependent upon Jagged-2, might be stronger after multilineage differentiation or influence from inflammatory factors. This may also be why rejection does not occur after allogeneic AMSCs differentiate into committed cells.

Indexed as

Cell DifferentiationImmunomodulationAdipose TissueApoptosisCell CommunicationCell MovementChondrogenesisCytokinesGene ExpressionHumansImmunophenotypingIntercellular Signaling Peptides and ProteinsInterferon-gammaJagged-2 ProteinLymphocyte ActivationLymphocyte Culture Test, MixedCytokinesIntercellular Signaling Peptides and ProteinsInterferon-gammaJAG2 protein, humanJagged-2 ProteinMembrane Proteins

Identifiers

PMID26412454
PMCPMC4585933

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.