Evidence map›Paper›PMID 26412380›Full record

ArticleAging2015

ARF: connecting senescence and innate immunity for clearance.

Alper Y Kearney, Benedict Anchang, Sylvia Plevritis, Dean W Felsher

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alper Y KearneyDivision of Oncology, Departments of Medicine and Pathology, Molecular Imaging Program, Stanford University, Stanford, CA 94305, USA.
Benedict AnchangDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
Sylvia PlevritisDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
Dean W FelsherDivision of Oncology, Departments of Medicine and Pathology, Molecular Imaging Program, Stanford University, Stanford, CA 94305, USA.
Stanford University · US

Funding

Modeling and Predicting Therapeutic Resistance of CancerU01CA188383 · NCI · STANFORD UNIVERSITY · PI FELSHER, DEAN W, GAMBHIR, SANJIV S · 2014 to 2018
$3.2M
Mechanisms by which Oncogene Inactivation Elicits Tumor Cell DeathR01CA170378 · NCI · STANFORD UNIVERSITY · PI FELSHER, DEAN W · 2012 to 2015
$2.1M
NCI NIH HHS R01 CA170378NCI NIH HHS U01 CA188383
6 · The paper itself

Abstract

We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment of innate immune activation. Our observations have possible implications for mechanisms of therapeutic resistance to targeted oncogene inactivation.

Indexed as

ADP-Ribosylation Factor 1AgingAnimalsGenes, p53HumansImmunity, InnateOncogenesADP-Ribosylation Factor 1innate immunityMyc inactivationp19arfsenescence

Identifiers

PMID26412380
PMCPMC4600620
OpenAlexW2322815791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.