Evidence map›Paper›PMID 26412291›Full record

ArticleThe journal of nutrition, health & aging2015

Associations of Protein Intake and Protein Source with Bone Mineral Density and Fracture Risk: A Population-Based Cohort Study.

L Langsetmo, S I Barr, C Berger, N Kreiger, E Rahme, J D Adachi, A Papaioannou, S M Kaiser, J C Prior, D A Hanley and 4 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of nutrition, health & aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 6 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 6 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Association between total and animal proteins with risk of fracture: A systematic review and dose-response meta-analysis of cohort studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Pooled it
  2. [Exercise therapy and basic treatment for osteoporosis].Orthopadie (Heidelberg, Germany) · 2023
    Guideline
  3. Pooled it
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  5. Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Pooled it
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  17. Nutrition and Osteoporosis Prevention.Current osteoporosis reports · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

L LangsetmoDavid Goltzman, Royal Victoria Hospital, CaMos, 687 Pine Ave W, Room E1.64, Montreal, QC H3A 1A1, Email: david.goltzman@mcgill.ca, Telephone: 514-843-1632, FAX: 514-843-1651.
S I Barr
C Berger
N Kreiger
E Rahme
J D Adachi
A Papaioannou
S M Kaiser
J C Prior
D A Hanley
C S Kovacs
R G Josse
D Goltzman
CaMos Research Group
McGill University · CAMcMaster University · CAUniversity of British Columbia · CAUniversity of Toronto · CADalhousie University · CAMemorial University of Newfoundland · CAUniversity of Calgary · CA

Funding

CIHR 88225-1
6 · The paper itself

Abstract

unlabelledHigh dietary protein has been hypothesized to cause lower bone mineral density (BMD) and greater fracture risk. Previous results are conflicting and few studies have assessed potential differences related to differing protein sources.

objectiveTo determine associations between total protein intake, and protein intake by source (dairy, non-dairy animal, plant) with BMD, BMD change, and incident osteoporotic fracture. DESIGN/

settingProspective cohort study (Canadian Multicentre Osteoporosis Study). Participants/Measures: Protein intake was assessed as percent of total energy intake (TEI) at Year 2 (1997-99) using a food frequency questionnaire (N=6510). Participants were contacted annually to ascertain incident fracture. Total hip and lumbar spine BMD was measured at baseline and Year 5. Analyses were stratified by group (men 25-49 y, men 50+ y, premenopausal women 25-49 y, and postmenopausal women 50+ y) and adjusted for major confounders. Fracture analyses were limited to those 50+ y.

resultsIntakes of dairy protein (with adjustment for BMI) were positively associated with total hip BMD among men and women aged 50+ y, and in men aged 25-49. Among adults aged 50+ y, those with protein intakes of <12% TEI (women) and <11% TEI (men) had increased fracture risk compared to those with intakes of 15% TEI. Fracture risk did not significantly change as intake increased above 15% TEI, and was not significantly associated with protein source.

conclusionsIn contrast to hypothesized risk of high protein, we found that for adults 50+ y, low protein intake (below 15% TEI) may lead to increased fracture risk. Source of protein was a determinant of BMD, but not fracture risk.

Indexed as

Dietary ProteinsEnergy IntakeAdultAnimalsBone DensityCanadaCohort StudiesDietFemaleHumansLumbar VertebraeMaleMiddle AgedOsteoporosisOsteoporotic FracturesPremenopauseDietary Proteins

Identifiers

PMID26412291
PMCPMC5092173
OpenAlexW1918712802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.