ArticleThe journal of nutrition, health & aging2015
Stress Regulation as a Link between Executive Function and Pre-Frailty in Older Adults.
Article in The journal of nutrition, health & aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Working memory training efficacy in COPD: the randomised, double-blind, placebo-controlled Cogtrain trial.ERJ open research · 2021Article
- Precipitous Dehydroepiandrosterone Declines Reflect Decreased Physical Vitality and Function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Global Performance of Executive Function Is Predictor of Risk of Frailty and Disability in Older Adults.The journal of nutrition, health & aging · 2017Article
- Effects of Acute Laboratory Stress on Executive Functions.Frontiers in psychology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesBoth pre-frailty and frailty are linked with impaired executive function (EF) but the mechanism underlying this relationship is not known. Williams and colleagues' model posits EF affects health outcomes via stress regulation. This model was utlized to test indicators of stress regulation as mediators of the relationship between EF and pre-frailty in older adults.
designCross-sectional.
settingAcademic general clinical research centers.
participants690 community-dwelling older adults ≥ 50 years of age. MEASUREMENTS: Pre-frailty was measured using a modified form of the Fried Frailty measure. EF was assessed via telephone-based neurocognitive assessments. Indicators of stress regulation included: stress exposure (measured by perceived stress), reactivity and recovery (measured by heart rate) and restoration (measured by serum interleukin-6 and sleep quality).
results396 individuals were classified as non-frail, 277 as pre-frail, and 17 as frail. Pre-frail and non-frail individuals were included in data analyses. Compared to non-frail individuals, pre-frail were older and exhibited poorer EF, higher levels of stress exposure and poorer stress restoration. Poorer EF was associated with greater stress exposure, less stress reactivity, longer stress recovery and poorer stress restoration. The total effect of the relationship between EF and pre-frailty was significant with significant indirect effects supporting stress exposure and restoration as mediators of the relationship.
conclusionStress exposure and restoration appear to mediate the relationship between EF and pre-frailty. Longitudinal studies are needed to clarify the direction of causality and determine whether stress regulation processes are appropriate targets for interventions aiming to prevent declines in EF and the development of pre-frailty.
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