Evidence map›Paper›PMID 26412084›Full record

SynthesisCurrent HIV/AIDS reports2015

The Impact of Alcohol Use and Related Disorders on the HIV Continuum of Care: a Systematic Review : Alcohol and the HIV Continuum of Care.

Panagiotis Vagenas, Marwan M Azar, Michael M Copenhaver, Sandra A Springer, Patricia E Molina, Frederick L Altice

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in Current HIV/AIDS reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04601064 (Peer Supported Collaborative Care to Increase Engagement in Mental Health and Substance Use Disorder Care in HIV Care Settings), which is not on this map. Cited by 143 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04601064 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Peer Supported Collaborative Care to Increase Engagement in Mental Health and Substance Use Disorder Care in HIV Care Settings

TypeinterventionalSponsorJohns Hopkins UniversityRan2022 to 2026Enrolled405ConditionsHIV Infections, Substance Use Disorders, Mental Health Disorder, AddictionArmsCollaborative Care Model
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Enhancing patient navigation with contingent financial incentives for substance use abatement in persons with HIV and substance use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
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  16. Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Panagiotis VagenasSection of Infectious Diseases, AIDS Program, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. p.vagenas@aya.yale.edu.
Marwan M AzarSection of Infectious Diseases, AIDS Program, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Michael M CopenhaverCenter for Health, Intervention, and Prevention, Department of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Sandra A SpringerSection of Infectious Diseases, AIDS Program, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Patricia E MolinaDepartment of Physiology, Alcohol and Drug Abuse Center of Excellence, Louisiana State University, New Orleans, LA, USA.
Frederick L AlticeSection of Infectious Diseases, AIDS Program, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Funding

Using Coincidence Analysis to Investigate Factors Affecting PrEP Initiation and Continuation in Southern ending the Epidemic CountiesP30MH062294 · NIMH · YALE UNIVERSITY · PI Trace S Kershaw · 2001 to 2026
$48.5M
HIV Testing and Treatment to Prevent Onward HIV Transmission among High-risk MSMR01DA032106 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUERR, ANN C · 2011 to 2015
$6.6M
Alcohol Pharmacotherapies Among Released PrisonersR01AA018944 · NIAAA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS, SPRINGER, SANDRA ANN · 2009 to 2013
$3.8M
HIV/AIDS & Alcohol-Related Outcomes:Translational Evidence-Based InterventionsU01AA021995 · NIAAA · LSU HEALTH SCIENCES CENTER · PI MOLINA, PATRICIA E. · 2012 to 2016
$3.4M
Enhancing Health Outcomes Among HIV+ Substance AbusersK24DA017072 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2003 to 2012
$1.5M
HIV Prevention and Adherence Among Priority Drug Using PopulationsK02DA033139 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI COPENHAVER, MICHAEL · 2013 to 2017
$697k
NIAAA NIH HHS R01 AA018944NIAAA NIH HHS U01 AA021995NIDA NIH HHS K02 DA033139NIDA NIH HHS K24 DA017072NIDA NIH HHS R01 DA032106NIMH NIH HHS P30 MH062294
6 · The paper itself

Abstract

Alcohol use is highly prevalent globally with numerous negative consequences to human health, including HIV progression, in people living with HIV (PLH). The HIV continuum of care, or treatment cascade, represents a sequence of targets for intervention that can result in viral suppression, which ultimately benefits individuals and society. The extent to which alcohol impacts each step in the cascade, however, has not been systematically examined. International targets for HIV treatment as prevention aim for 90 % of PLH to be diagnosed, 90 % of them to be prescribed with antiretroviral therapy (ART), and 90 % to achieve viral suppression; currently, only 20 % of PLH are virally suppressed. This systematic review, from 2010 through May 2015, found 53 clinical research papers examining the impact of alcohol use on each step of the HIV treatment cascade. These studies were mostly cross-sectional or cohort studies and from all income settings. Most (77 %) found a negative association between alcohol consumption on one or more stages of the treatment cascade. Lack of consistency in measurement, however, reduced the ability to draw consistent conclusions. Nonetheless, the strong negative correlations suggest that problematic alcohol consumption should be targeted, preferably using evidence-based behavioral and pharmacological interventions, to indirectly increase the proportion of PLH achieving viral suppression, to achieve treatment as prevention mandates, and to reduce HIV transmission.

Indexed as

Alcohol DrinkingAlcoholismAnti-HIV AgentsDrug Administration ScheduleHIV InfectionsHumansAnti-HIV AgentsAdherenceAlcoholismAlcohol use disordersAntiretroviral therapyARTHIVHIV continuum of careHIV treatment cascadeViral suppression

Identifiers

PMID26412084
PMCPMC4643391

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.