ReviewCurrent neuropharmacology2015
The Neurobiological Mechanisms and Treatments of REM Sleep Disturbances in Depression.
Review in Current neuropharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 3 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Anti-inflammatory effects of immunotherapy in clinical treatment and its potential mechanism in alleviating sleeping disorders: A systematic bibliometric study.Human vaccines & immunotherapeutics · 2025Pooled it
- Narcolepsy and psychosis: A systematic review.Acta psychiatrica Scandinavica · 2021Pooled it
- Pooled it
- Effect of Intraoperative Intravenous Infusion of Esketamine Combined with Dexmedetomidine on Postoperative Sleep Disturbance in Patients Undergoing Radical Mastectomy.Drug design, development and therapy · 2025Trial
- A neural regulation mechanism of head electroacupuncture on brain network of patients with stroke related sleep disorders.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Trial
- Restorative or Disruptive? Effects of Antidepressants on Sleep Architecture in Depression.CNS drugs · 2026Review
- A review of neurophysiological relationships between sleep disorders and depression.Brain, behavior, & immunity - health · 2026Review
- Obstructive sleep apnea's causal links to depression, well-being, and negative moods: a bidirectional mendelian randomized study.European archives of psychiatry and clinical neuroscience · 2026Article
- Association of severe depression with bone mineral content: a mediation analysis in PERSIAN cohort study.BMC public health · 2026Article
- Effects of exercise supplementary to standard therapy on cognition and sleep in depression: a randomised controlled trial.Frontiers in psychiatry · 2026Article
- Sex differences in sleep architecture among patients with severe mental disorders: a polysomnographic study.Frontiers in psychiatry · 2026Article
- Network analysis of interrelationships among physical activity, sleep disturbances, depression, and anxiety in college students.BMC psychiatry · 2025Article
- Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with obstructive sleep apnea: a cross-sectional study.Lipids in health and disease · 2025Article
- Compound 38, a novel potent and selective antagonist of adenosine AActa pharmacologica Sinica · 2025Article
- Association Between the Dietary Inflammatory Index and Depression in Mid-Pregnancy: Mediating Effect of Sleep Quality.Nutrients · 2025Article
- Association between sleep patterns and depression in older adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2007-2014.BMC geriatrics · 2025Article
- Exploring influencing factors of healthy lifestyles in rural area among older adults with diabetes based on socioecological model.Scientific reports · 2025Article
- Memory control deficits in the sleep-deprived human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of physical activity on sleep quality among university students: chain mediation between rumination and depression levels.BMC psychiatry · 2025Article
- Patterns of Sleep Quality and Their Associations With Depressive and Anxiety Symptoms Among Chinese Coronary Heart Disease Patients: A Latent Class Analysis.Depression and anxiety · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most depressed patients suffer from sleep abnormalities, which are one of the critical symptoms of depression. They are robust risk factors for the initiation and development of depression. Studies about sleep electroencephalograms have shown characteristic changes in depression such as reductions in non-rapid eye movement sleep production, disruptions of sleep continuity and disinhibition of rapid eye movement (REM) sleep. REM sleep alterations include a decrease in REM sleep latency, an increase in REM sleep duration and REM sleep density with respect to depressive episodes. Emotional brain processing dependent on the normal sleep-wake regulation seems to be failed in depression, which also promotes the development of clinical depression. Also, REM sleep alterations have been considered as biomarkers of depression. The disturbances of norepinephrine and serotonin systems may contribute to REM sleep abnormalities in depression. Lastly, this review also discusses the effects of different antidepressants on REM sleep disturbances in depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.