ArticleScientific reports2015
Genomic and transcriptomic insights into the efficient entomopathogenicity of Bacillus thuringiensis.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Decoding the genome of Bacillus thuringiensis subsp. israelensis VCRC B668 to understand its mosquitocidal potential for biopesticide development.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Review
- Genome mining of Bacillus thuringiensis strain SY49.1 reveals novel candidate pesticidal and bioactive compounds.Pest management science · 2025Article
- Taxonomic refinement ofFrontiers in microbiology · 2025Article
- Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 21: Suitability of taxonomic units notified to EFSA until September 2024.EFSA journal. European Food Safety Authority · 2025Article
- Draft genome of neotropical Bacillus thuringiensis UFT038 and its potential against lepidopteran soybean pests.Folia microbiologica · 2024Article
- First report on in-depth genome and comparative genome analysis of a metal-resistant bacteriumFrontiers in microbiology · 2024Article
- Thurincin H Is a Nonhemolytic Bacteriocin of Bacillus thuringiensis with Potential for Applied Use.Probiotics and antimicrobial proteins · 2023Article
- Whole genome sequencing of a novel Bacillus thuringiensis isolated from Assam soil.BMC microbiology · 2023Article
- Genomic-proteomic analysis of a novel Bacillus thuringiensis strain: toxicity against two lepidopteran pests, abundance of Cry1Ac5 toxin, and presence of InhA1 virulence factor.Archives of microbiology · 2023Article
- Identification of Genetic Markers for the Detection ofFoods (Basel, Switzerland) · 2022Article
- Expression of the Bacillus thuringiensisMicrobiology spectrum · 2022Article
- Draft Genome Sequence of Bacillus thuringiensis ZZQ-130 with Multiple Pesticidal Genes, Isolated from Caka Salt Lake, China.Microbiology resource announcements · 2022Article
- Bt GS57 Interaction With Gut Microbiota AcceleratesFrontiers in microbiology · 2022Article
- Creation of an IndustrialFrontiers in microbiology · 2022Article
- Ultraviolet protection of Bacillus thuringiensis through microencapsulation with Pickering emulsion method.Scientific reports · 2020Article
- Genomics and Proteomics Analyses Revealed Novel Candidate Pesticidal Proteins in a Lepidopteran-ToxicToxins · 2020Article
- The CRISPR-Cas systems were selectively inactivated during evolution of Bacillus cereus group for adaptation to diverse environments.The ISME journal · 2020Article
- Characterization ofFrontiers in microbiology · 2020Article
- Effect of Chlorine and Temperature on Larvicidal Activity of CubanJournal of arthropod-borne diseases · 2019Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus thuringiensis has been globally used as a microbial pesticide for over 70 years. However, information regarding its various adaptions and virulence factors and their roles in the entomopathogenic process remains limited. In this work, we present the complete genomes of two industrially patented Bacillus thuringiensis strains (HD-1 and YBT-1520). A comparative genomic analysis showed a larger and more complicated genome constitution that included novel insecticidal toxicity-related genes (ITRGs). All of the putative ITRGs were summarized according to the steps of infection. A comparative genomic analysis showed that highly toxic strains contained significantly more ITRGs, thereby providing additional strategies for infection, immune evasion, and cadaver utilization. Furthermore, a comparative transcriptomic analysis suggested that a high expression of these ITRGs was a key factor in efficient entomopathogenicity. We identified an active extra urease synthesis system in the highly toxic strains that may aid B. thuringiensis survival in insects (similar to previous results with well-known pathogens). Taken together, these results explain the efficient entomopathogenicity of B. thuringiensis. It provides novel insights into the strategies used by B. thuringiensis to resist and overcome host immune defenses and helps identify novel toxicity factors.
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