ArticleThe international journal of cardiovascular imaging2016
Atrial fibrillation is associated with hematopoietic tissue activation and arterial inflammation.
Article in The international journal of cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis.Medical science monitor basic research · 2017Pooled it
- Dissecting and Visualizing the Functional Diversity of Cardiac Macrophages.Circulation research · 2024Review
- Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels.European journal of medical research · 2024Article
- Article
- Series of myocardial FDG uptake requiring considerations of myocardial abnormalities in FDG-PET/CT.Japanese journal of radiology · 2021Review
- Factors relevant to atrialJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- FDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation.European journal of nuclear medicine and molecular imaging · 2019Article
- Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Associated With Decreased Incidence of Atrial Fibrillation.Journal of the American Heart Association · 2017Article
- Presence of atrial fibrillation is associated with liver stiffness in an elderly Finnish population.PloS one · 2017Article
- Cardiovascular imaging 2015 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2016Review
- Topical issue: multimodality imaging in atherosclerosis.The international journal of cardiovascular imaging · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Inflammation is associated with the development of atrial fibrillation (AF). Activity in hematopoietic tissues, which produce inflammatory leukocytes, is closely related to systemic inflammation, arterial inflammation and cardiovascular events, but its relationship to AF is unknown. Using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging, we examined the relationships between AF, splenic metabolic activity and vascular inflammation. We conducted a cross sectional study of 70 participants: 35 with AF, who were matched (by age, sex and history of active cancer) to 35 controls without AF. Splenic metabolic activity and vascular aortic inflammation were measured by the mean FDG maximum standard uptake values (SUV Max) by PET. We examined (1) the association between AF and splenic activity, and (2) AF and aortic inflammation. The mean age of the population was 68.13 (standard deviation (SD) 8.98) years and 46 (65 %) participants were male. Splenic activity was higher in AF participants [2.31 (SD 0.45) vs. 2.07 (SD 0.37), p = 0.024], and remained significant after adjusting for demographic and clinical covariates. Aortic inflammation was also higher in AF participants [2.22 (SD 0.44) vs. 1.91 (SD 0.44), p = 0.004], and remained significant on multivariable analysis. Aortic inflammation and splenic activity were highly correlated (Pearson R = 0.61, p < 0.001). Atrial fibrillation is associated with higher hematopoietic tissue activation and arterial inflammation. Further studies are needed to clarify the mechanisms by which this cardio-splenic axis is implicated in AF.
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Registered trials
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