SynthesisClinical nutrition (Edinburgh, Scotland)2016
A systematic review of the nutritional consequences of esophagectomy.
Synthesis in Clinical nutrition (Edinburgh, Scotland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05074914 (Mechanisms and Treatment of Unintentional Weight Loss After Oesophagectomy With Curative Intent), which is not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanisms and Treatment of Unintentional Weight Loss After Oesophagectomy With Curative Intent
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Home enteral nutrition for patients with esophageal cancer undergoing esophagectomy: A systematic review and meta-analysis.Frontiers in nutrition · 2022Pooled it
- Effect of Home Enteral Nutritional Support Compared With Normal Oral Diet in Postoperative Subjects With Upper Gastrointestinal Cancer Resection: A Meta-Analysis.Frontiers in surgery · 2022Pooled it
- Home enteral nutrition after esophagectomy for esophageal cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Trial
- Trial
- QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Trial
- Nutrient intake and contribution of home enteral nutrition to meeting nutritional requirements after oesophagectomy and total gastrectomy.European journal of clinical nutrition · 2017Trial
- Trial
- Return to work after upper gastrointestinal cancer surgery: questionnaire-based observational study.International journal of clinical oncology · 2026Observational
- Clinical predictors of early reflux and symptom severity after esophagectomy: a risk prediction tool.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Utility and outcomes of routine jejunostomy placement following oesophagectomy.Annals of the Royal College of Surgeons of England · 2026Article
- Changes in Components of Sarcopenia Diagnostic Criteria Throughout the Surgical Treatment of Oesophagogastric Cancer Surgery: A Prospective Longitudinal Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Observational
- Short- and Long-Term Outcomes after Pancreatectomy for Pancreatic Cancer in Patients with Prior Esophagectomy for Esophageal Cancer.Annals of surgical oncology · 2026Article
- Nutritional aspects and quality of life in gastroesophageal cancer patients that underwent colonic interposition.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026Observational
- The distress of psychological adaptation in nutritional management among people after esophagectomy: an interpretative phenomenological study.Frontiers in nutrition · 2026Article
- Commentary: The distress of psychological adaptation in nutritional management among people after esophagectomy: an interpretative phenomenological study.Frontiers in nutrition · 2026Article
- Investigating Nutrition and Supportive Care Needs in Esophageal and Gastric Cancer Survivors: A Cross-Sectional Survey.Healthcare (Basel, Switzerland) · 2025Article
- Primary tumor location is a risk factor for postoperative development of sarcopenia as a predictive marker for unfavorable outcomes in patients with colorectal cancer.International journal of clinical oncology · 2025Article
- Successful Prevention of Bronchopleural Fistula in Single-Stage Esophagectomy and Right Lower Lobectomy: A Case Report.Surgical case reports · 2025Article
- Intensified outpatient nutrition management improves body weight and skeletal muscle loss after esophageal cancer surgery: a single-center, retrospective, single-arm clinical study.Langenbeck's archives of surgery · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsAs improved outcomes after esophagectomy have been observed over the last two decades, the focus on care has shifted to survivorship and quality of life. The aim of this review was to determine changes in nutrition after esophagectomy and to assess the evidence for extended nutrition support.
methodsA search strategy was developed to identify primary research reporting change in nutritional status a minimum of one month after esophagectomy.
resultsChanges in nutritional parameters reported by 18 studies indicated a weight loss of 5-12% at six months postoperatively. More than half of patients lost >10% of body weight at 12 months. One study reported a persistent weight loss of 14% from baseline three years after surgery. Three studies reporting on longer term follow up noted that 27%-95% of patients failed to regain their baseline weight. Changes in dietary intake (three studies) indicated inadequate energy and protein intake up to three years after surgery. Global quality of life scores reported in one study correlated with better weight preservation. There were a high frequency of gastrointestinal symptoms reported in six studies, most notably in the first year after surgery, but persisting up to 19 years. Extended enteral nutrition on a selective basis has been reported in several studies.
conclusionsNutritional status is compromised in the months/years following oesophagectomy and may never return to baseline levels. The causes/consequences of weight loss/impaired nutritional intake require further investigation. The role of extended nutritional support in this population remains unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.