ArticleLung2016
Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function.
Article in Lung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Maternal asthma and the role of stress, sensitization, and lung function on pregnancy outcomes: MAESTRO cohort study.The journal of allergy and clinical immunology. Global · 2026Article
- Causal Associations Between Chronic Obstructive Pulmonary Disease and Common Comorbidities: Evidence from Comprehensive Genetic Methods.International journal of chronic obstructive pulmonary disease · 2025Article
- Does fetal leptin and adiponectin influence children's lung function and risk of wheeze?Journal of developmental origins of health and disease · 2021Article
- Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults.Lipids in health and disease · 2020Article
- Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner.PloS one · 2019Article
- Longitudinal study of the influence of lung function on vascular health from adolescence to early adulthood in a British multiethnic cohort.Journal of hypertension · 2017Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionReduced lung function is associated with a risk for the development of cardiovascular disease. This association may be due to chronic inflammation which is often present in those with reduced lung function. PURPOSE: We investigated the possible role of systemic inflammation as the mediator between lung function and arterial stiffness in 1534 black South Africans.
methodsSpirometric data including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were obtained. C-reactive protein (CRP), interleukin-6 (IL-6), blood pressure (BP) and carotid-radial pulse wave velocity (PWV) were determined.
resultsIn multivariable-adjusted models, an independent inverse association was found between IL-6 and FEV1 (β = -0.20, p < 0.001) and FVC (β = -0.18, p < 0.001). Similar results were found for CRP. PWV was inversely associated with FEV1 (β = -0.06, p = 0.037). No association was found between inflammatory markers, BP or PWV.
conclusionReduced lung function was associated with increased inflammation and arterial stiffness. The lack of association between arterial stiffness and inflammatory markers suggests that inflammation may not be the mediating link between lung and vascular function in this population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.