Evidence map›Paper›PMID 26411502›Full record

ReviewParkinsonism & related disorders2016

Adaptive deep brain stimulation in Parkinson's disease.

M Beudel, P Brown

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Parkinsonism & related disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03079960 (Data-Driven Characterization of Neuronal Markers During Deep Brain Stimulation for Patients With Parkinson's Disease), which is not on this map. Cited by 72 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03079960 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Data-Driven Characterization of Neuronal Markers During Deep Brain Stimulation for Patients With Parkinson's Disease

TypeinterventionalSponsorProf. Dr. Volker Arnd CoenenRan2017 to 2021Enrolled120ConditionsParkinson DiseaseArmsElectrophysiological recording and measurement devices
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  7. Review
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  10. Review
  11. Article
  12. Review
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  18. Review
  19. Frontiers in neuroscience · 2025
    Review
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

M BeudelDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
P BrownNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, UK; The Medical Research Council Brain Network Dynamics Unit at the University of Oxford, OX1 3TH, UK. Electronic address: peter.brown@ndcn.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although Deep Brain Stimulation (DBS) is an established treatment for Parkinson's disease (PD), there are still limitations in terms of effectivity, side-effects and battery consumption. One of the reasons for this may be that not only pathological but also physiological neural activity can be suppressed whilst stimulating. For this reason, adaptive DBS (aDBS), where stimulation is applied according to the level of pathological activity, might be advantageous. Initial studies of aDBS demonstrate effectiveness in PD, but there are still many questions to be answered before aDBS can be applied clinically. Here we discuss the feedback signals and stimulation algorithms involved in adaptive stimulation in PD and sketch a potential road-map towards clinical application.

Indexed as

AnimalsBrain-Computer InterfacesDeep Brain StimulationHumansHypokinesiaParkinson DiseaseSubthalamic NucleusTremorBrain-computer interfaceDeep brain stimulationParkinson's disease

Identifiers

PMID26411502
PMCPMC4671979

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.