ArticleJournal of natural medicines2016
ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells.
Article in Journal of natural medicines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- LC-ESI QToF MS Non-Targeted Screening of Latex Extracts ofPlants (Basel, Switzerland) · 2023Article
- Camalexin, an indole phytoalexin, inhibits cell proliferation, migration, and mammosphere formation in breast cancer cells via the aryl hydrocarbon receptor.Journal of natural medicines · 2022Article
- Integrated Strategy of UHPLC-Q-TOF-MS and Molecular Networking for Identification of Diterpenoids fromEvidence-based complementary and alternative medicine : eCAM · 2021Article
- High-throughput sequencing analysis of3 Biotech · 2018Article
- Structural Diversity and Biological Activities of Diterpenoids Derived fromMolecules (Basel, Switzerland) · 2018Review
- Anti-Cancer Activities of Diterpenoids Derived from Euphorbia fischeriana Steud.Molecules (Basel, Switzerland) · 2018Review
- Jolkinolide A and Jolkinolide B Inhibit Proliferation of A549 Cells and Activity of Human Umbilical Vein Endothelial Cells.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Euphorins A-H: bioactive diterpenoids from Euphorbia fischeriana.Journal of natural medicines · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of new drugs that target cancer stem cells (CSCs) is a critical approach to overcome the major difficulties of the metastasis, chemotherapeutic resistance and recurrence for successful cancer therapy. Chemical investigation of the roots of Euphorbia fischeriana resulted in the isolation of eight ent-atisane diterpenoids (1-8), including two new compounds: 19-O-β-D-glucopyranosyl-ent-atis-16-ene-3,14-dione (7) and 19-O-(6-galloyl)-β-D-glucopyranosyl-ent-atis-16-ene-3,14-dione (8). The structures were elucidated on extensive spectroscopic analyses, as well as chemical transformations. ent-3β-Hydroxyatis-16-ene-2,14-dione (5), 7 and its aglycon, ent-19-hydroxy-atis-16-ene-3,14-dione (7a), showed significant inhibitory activity on mammosphere formation in human breast cancer MCF-7 cells at a final concentration of 10 μM.
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Registered trials
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