Evidence map›Paper›PMID 26411443›Full record

ArticleJournal of materials science. Materials in medicine2015

Indirect additive manufacturing as an elegant tool for the production of self-supporting low density gelatin scaffolds.

Jasper Van Hoorick, Heidi Declercq, Amelie De Muynck, Annemie Houben, Luc Van Hoorebeke, Ria Cornelissen, Jürgen Van Erps, Hugo Thienpont, Peter Dubruel, Sandra Van Vlierberghe

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Optimized Photoclick (Bio)Resins for Fast Volumetric Bioprinting.Advanced materials (Deerfield Beach, Fla.) · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jasper Van HoorickPolymer Chemistry & Biomaterials Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-Bis, 9000, Ghent, Belgium.
Heidi DeclercqDepartment of Basic Medical Sciences, Ghent University, De Pintelaan 185 6B3, 9000, Ghent, Belgium.
Amelie De MuynckUGCT - Department of Physics and Astronomy, Ghent University, Proeftuinstraat 86/N12, 9000, Ghent, Belgium.
Annemie HoubenPolymer Chemistry & Biomaterials Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-Bis, 9000, Ghent, Belgium.
Luc Van HoorebekeUGCT - Department of Physics and Astronomy, Ghent University, Proeftuinstraat 86/N12, 9000, Ghent, Belgium.
Ria CornelissenDepartment of Basic Medical Sciences, Ghent University, De Pintelaan 185 6B3, 9000, Ghent, Belgium.
Jürgen Van ErpsBrussels Photonics Team, Department of Applied Physics and Photonics, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Elsene, Belgium.
Hugo ThienpontBrussels Photonics Team, Department of Applied Physics and Photonics, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Elsene, Belgium.
Peter DubruelPolymer Chemistry & Biomaterials Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-Bis, 9000, Ghent, Belgium. peter.dubruel@ugent.be.
Sandra Van VlierberghePolymer Chemistry & Biomaterials Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-Bis, 9000, Ghent, Belgium. sandra.vanvlierberghe@ugent.be.
Ghent University · BEVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present work describes for the first time the production of self-supporting low gelatin density (<10 w/v%) porous scaffolds using methacrylamide-modified gelatin as an extracellular matrix mimicking component. As porous scaffolds starting from low gelatin concentrations cannot be realized with the conventional additive manufacturing techniques in the abscence of additives, we applied an indirect fused deposition modelling approach. To realize this, we have printed a sacrificial polyester scaffold which supported the hydrogel material during UV crosslinking, thereby preventing hydrogel structure collapse. After complete curing, the polyester scaffold was selectively dissolved leaving behind a porous, interconnective low density gelatin scaffold. Scaffold structural analysis indicated the success of the selected indirect additive manufacturing approach. Physico-chemical testing revealed scaffold properties (mechanical, degradation, swelling) to depend on the applied gelatin concentration and methacrylamide content. Preliminary biocompatibility studies revealed the cell-interactive and biocompatible properties of the materials developed.

Indexed as

AnimalsBiocompatible MaterialsCalorimetry, Differential ScanningCattleCell LineFibroblastsGelatinHumansHydrogelsMaterials TestingPorosityRheologySurface PropertiesTissue EngineeringTissue ScaffoldsBiocompatible MaterialsGelatinHydrogels

Identifiers

PMID26411443
OpenAlexW2196228336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.