ArticleClinical research in cardiology : official journal of the German Cardiac Society2016
Monocyte-platelet aggregates and CD11b expression as markers for thrombogenicity in atrial fibrillation.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation.Heart (British Cardiac Society) · 2019Trial
- Thrombi from stroke due to cardioembolic etiology have higher CD11b-positive cells compared to large artery atherosclerosis.Journal of thrombosis and thrombolysis · 2026Article
- Subclinical atrial fibrillation: Implications of recent trials for guideline updates?World journal of cardiology · 2026Review
- Routinely available inflammation biomarkers to predict stroke and mortality in atrial fibrillation.Clinics (Sao Paulo, Brazil) · 2025Article
- Platelet-Leukocyte Aggregate and Interleukin-6: An Emerging Perspective on a New Diagnostic and Therapeutic Clue for Acute Coronary Syndrome, A Case-Control Study.Health science reports · 2024Article
- Relationship of inflammatory indices with left atrial appendage thrombus or spontaneous echo contrast in patients with atrial fibrillation.World journal of clinical cases · 2024Article
- Circulating monocyte populations as biomarker for abdominal aortic aneurysms: a single-center retrospective cohort study.Frontiers in immunology · 2024Article
- Identification of immune-related biomarkers co-occurring in acute ischemic stroke and acute myocardial infarction.Frontiers in neurology · 2023Article
- The role of monocytes in thrombotic diseases: a review.Frontiers in cardiovascular medicine · 2023Review
- Exosomes in atrial fibrillation: therapeutic potential and role as clinical biomarkers.Heart failure reviews · 2022Review
- Predictive value of lymphocyte-to-monocyte ratio in critically Ill patients with atrial fibrillation: A propensity score matching analysis.Journal of clinical laboratory analysis · 2022Article
- Review
- Thrombin Generation and other hemostatic parameters in patients with atrial fibrillation in use of warfarin or rivaroxaban.Journal of thrombosis and thrombolysis · 2021Article
- CD11b expression on monocytes and data of inflammatory parameters after Transcatheter Aortic Valve Implantation in dependence of early mortality.Data in brief · 2020Article
- Inflammation and the risk of atrial high-rate episodes (AHREs) in patients with cardiac implantable electronic devices.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Impaired Production and Diurnal Regulation of Vascular RvDCirculation research · 2018Article
- Papain Ameliorates the MPAs Formation-Mediated Activation of Monocytes by Inhibiting Cox-2 Expression via Regulating the MAPKs and PI3K/Akt Signal Pathway.BioMed research international · 2018Article
- 13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Coagulation Abnormalities in Heart Failure: Pathophysiology and Therapeutic Implications.Current heart failure reports · 2016Review
- Latent trajectory modeling of platelet counts and mortality risk in intensive care unit patients with atrial fibrillation.Science progressArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA strong interdependence is known between atrial fibrillation (AF), inflammation and thrombogenesis. Monocyte-platelet aggregates (MPAs) are sensitive markers of platelets and monocyte activation. It is not known whether MPAs are associated with thrombogenicity in AF. Therefore, we examined differences in the content of MPAs and CD11b expression in patients with AF in dependence of the presence of atrial thrombus formation.
methods107 patients with symptomatic AF underwent transesophageal echocardiography (TEE) before planned cardioversion or pulmonary vein isolation. Flow-cytometric quantification analysis was done on the day of performed TEE to determine the content of MPAs and the expression of CD11b on monocytes and granulocytes.
resultsCompared to patients without thrombus (n = 80) those with an echocardiographic proven left atrium (LA) thrombus (n = 27) showed an increased extent of the risk factors age, diabetes and heart failure. The content of MPAs (147 ± 12 vs. 311 ± 29 cells/µl, p < 0.001) as well as the CD11b expression on monocytes (p < 0.05) and granulocytes (p < 0.05) were strongly associated with the existence of a LA thrombus. The content of MPAs and the CD11b expression remained independent predictors for LA thrombus after adjustment in logistic regression analysis and negatively correlated with left atrial appendage flow velocity. MPAs above 170 cells/µl (OR 34.2, p = 0.01) had a sensitivity of 96 % and a specificity of 73 % for predicting LA-thrombus.
conclusionsThe content of MPAs and the CD11b expression on monocytes and granulocytes are increased in AF-patients with proven thrombus formation. They seem to be appropriate biomarkers for stratification of thromboembolic risk in patients with AF.
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