Evidence map›Paper›PMID 26410803›Full record

ArticleInternational journal of surgery case reports2015

Wernicke encephalopathy as rare complication of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

Antonio Macrì, Francesco Fleres, Antonio Ieni, Maurizio Rossitto, Tommaso Mandolfino, Salvatore Micalizzi, Francesco Iaropoli, Carmelo Mazzeo, Massimo Trovato, Eugenio Cucinotta and 1 more

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In one paragraph

Article in International journal of surgery case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Antonio MacrìDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Francesco FleresDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy. Electronic address: franz.fleres@gmail.com.
Antonio IeniDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Maurizio RossittoDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Tommaso MandolfinoAnesthesiology and Neuroreanimation Unit, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Salvatore MicalizziAnesthesiology and Neuroreanimation Unit, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Francesco IaropoliDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Carmelo MazzeoDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Massimo TrovatoDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Eugenio CucinottaDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Edoardo SaladinoDepartment of Human Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeritoneal carcinomatosis of gastric origin is a frequent event with poor survival. A new promising approach is the association of the Cytoreductive Surgery (CRS) with the Hyperthermic Intraperitoneal Chemotherapy (HIPEC), which yet is characterized by high morbidity and mortality. We report, to our knowledge, the first case of Wernicke Encephalopathy (WE) complicating CRS plus HIPEC. WE, caused by a deficiency of thiamine, is characterized by ataxia, ocular motor cranial neuropathies and changes in consciousness.

methodsA patient affected by gastric cancer with peritoneal seeding, submitted to CRS plus HIPEC, in 4th post-operative day had manifested the appearance of flapping tremors, with positive manoeuvre of Mingazzini, impaired vision and mental confusion. The brain Magnetic Resonance Imaging (MRI) confirmed the clinical suspicion of WE. Even though the appropriate therapy was promptly applied, the patient died in 10th post-operative day.

conclusionWE is an uncommon neurological disorder. Only 16% of these patients inadequately treated recover fully, with a mortality rate of 10-20%. We consider useful to report this case, because it is the first time that WE is correlated to CRS plus HIPEC.

Indexed as

ComplicationsGastric cancerHIPECPeritoneal carcinomatosisWernicke Encephalopathy

Identifiers

PMID26410803
PMCPMC4643342
OpenAlexW2218690844

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.