ArticleJournal of neurology2015
Morphometric changes in the reward system of Parkinson's disease patients with impulse control disorders.
Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Association between air pollution exposure and brain cortical thickness throughout the lifespan: A systematic review.Neuroscience · 2024Pooled it
- Exploring brain changes of impulse control disorders in Parkinson's disease: An ALE study.Frontiers in aging neuroscience · 2022Pooled it
- Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease.Frontiers in neurology · 2021Pooled it
- The impact of impulse control disorders on cognitive decline inFrontiers in neurology · 2025Article
- Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's disease.Translational psychiatry · 2024Article
- Impulse Control Disorders in Parkinson's Disease: An Overview of Risk Factors, Pathogenesis and Pharmacological Management.CNS drugs · 2024Review
- Increased Cortical Thickness in Alzheimer's Disease.Annals of neurology · 2024Article
- Anatomical correlates of apathy and impulsivity co-occurrence in early Parkinson's disease.Journal of neurology · 2024Article
- Morphometric alterations of the mesocorticolimbic network in Parkinson's disease with impulse control disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Nucleus accumbens atrophy in Parkinson's disease (Mavridis' atrophy): 10 years later.American journal of neurodegenerative disease · 2022Review
- Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease.Journal of personalized medicine · 2021Article
- Unmasking neurobiological commonalities between addictive disorders and impulse control disorders in Parkinson's disease.Brain imaging and behavior · 2020Review
- Preservation of brain metabolism in recently diagnosed Parkinson's impulse control disorders.European journal of nuclear medicine and molecular imaging · 2020Article
- Brain Imaging and Impulse Control Disorders in Parkinson's Disease.Current neurology and neuroscience reports · 2019Review
- Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's Disease.Frontiers in neurology · 2019Article
- Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease.Frontiers in neurology · 2019Article
- Impulse Control Disorders in Parkinson's Disease. A Brief and Comprehensive Review.Frontiers in neurology · 2019Article
- The neurobiology of impulse control disorders in Parkinson's disease: from neurotransmitters to neural networks.Cell and tissue research · 2018Review
- Brain structural and functional signatures of impulsive-compulsive behaviours in Parkinson's disease.Molecular psychiatry · 2018Article
- Do Patients With Parkinson's Disease Exhibit Reduced Cheating Behavior? A Neuropsychological Study.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Impulse control disorders (ICDs) occur in a subset of patients with Parkinson's disease (PD) who are receiving dopamine replacement therapy. In this study, we aimed to investigate structural abnormalities within the mesocortical and limbic cortices and subcortical structures in PD patients with ICDs. We studied 18 PD patients with ICDs, 18 PD patients without ICDs and a group of 24 age and sex-matched healthy controls. Cortical thickness (CTh) and subcortical nuclei volume analyses were carried out using the automated surface-based analysis package FreeSurfer (version 5.3.0). We found significant differences in MRI measures between the three groups. There was volume loss in the nucleus accumbens of both PD patients with ICDs and without ICDs compared to the control group. In addition, PD patients with ICDs showed significant atrophy in caudate, hippocampus and amygdala compared to the group of healthy controls. PD patients with ICDs had significant increased cortical thickness in rostral anterior cingulate cortex and frontal pole compared to PD patients without ICDs. Cortical thickness in rostral anterior cingulate and frontal pole was increased in PD patients with ICDs compared to the control group, but the differences failed to reach corrected levels of statistical significance. PD patients with ICDs showed increased cortical thickness in medial prefrontal regions. We speculate that these findings reflect either a pre-existing neural trait vulnerability to impulsivity or the expression of a maladaptive synaptic plasticity under non-physiological dopaminergic stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.