ArticleThe Science of the total environment2016
Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study.
Article in The Science of the total environment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Prevalence and associated factors of congenital anomalies in Ethiopia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Pooled it
- Light at night exposure and risk of dementia conversion from mild cognitive impairment in a Northern Italy population.International journal of health geographics · 2024Article
- Associations between occurrence of birth defects and hydraulic fracturing activities in Barnett shale region, Texas.Heliyon · 2023Article
- Association between maternal exposure to PMEnvironmental science and pollution research international · 2022Article
- Association Between Maternal Exposure to SOInternational journal of public health · 2022Article
- First trimester exposure to ambient gaseous air pollutants and risk of orofacial clefts: a case-control study in Changsha, China.BMC oral health · 2021Article
- Risk of Amyotrophic Lateral Sclerosis and Exposure to Particulate Matter from Vehicular Traffic: A Case-Control Study.International journal of environmental research and public health · 2021Article
- Maternal PMFrontiers in public health · 2021Article
- Maternal exposure to outdoor air pollution and congenital limb deficiencies in the National Birth Defects Prevention Study.Environmental research · 2019Article
- Land use regression for spatial distribution of urban particulate matter (PMEnvironmental monitoring and assessment · 2019Article
- Local- and regional-scale air pollution modelling (PMEnvironment international · 2018Article
- Multiple linear regression and regression with time series error models in forecasting PMEnvironmental monitoring and assessment · 2018Article
- Congenital heart defects of fetus after maternal exposure to organic and inorganic environmental factors: a cohort study.Oncotarget · 2017Article
- Effects of Prenatal PMEnvironmental health perspectives · 2017Article
- Determinants of serum manganese levels in an Italian population.Molecular medicine reports · 2017Article
- Day-night variability of water-soluble ions in PMEnvironmental science and pollution research international · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
A few studies have suggested an association between maternal exposure to ambient air pollution from vehicular traffic and risk of congenital anomalies in the offspring, but epidemiologic evidence is neither strong nor entirely consistent. In a population-based case-control study in a Northern Italy community encompassing 228 cases of birth defects and 228 referent newborns, we investigated if maternal exposure to PM10 and benzene from vehicular traffic during early pregnancy, as estimated through a dispersion model, was associated with excess teratogenic risk. In conditional logistic regression analysis, and with adjustment for the other pollutant, we found that higher exposure to PM10 but not benzene was associated with increased risk of birth defects overall. Anomaly categories showing the strongest dose-response relation with PM10 exposure were musculoskeletal and chromosomal abnormalities but not cardiovascular defects, with Down syndrome being among the specific abnormalities showing the strongest association, though risk estimates particularly for the less frequent defects were statistically very unstable. Further adjustment in the regression model for potential confounders did not considerably alter the results. All the associations were stronger for average levels of PM10 than for their maximal level. Findings of this study give some support for an excess teratogenic risk following maternal exposure during pregnancy to PM10, but not benzene. Such association appears to be limited to some birth defect categories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.