Evidence map›Paper›PMID 26410545›Full record

ArticleClinical drug investigation2015

The T-peak-T-end interval as a marker of repolarization abnormality: a comparison with the QT interval for five different drugs.

Tanveer A Bhuiyan, Claus Graff, Jørgen K Kanters, Jimmi Nielsen, Jacob Melgaard, Jørgen Matz, Egon Toft, Johannes J Struijk

Abstract read
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Article in Clinical drug investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Comparing the consistency of electrocardiogram interval measurements by resting ECG versus 12-lead Holter.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021
    Trial
  2. Trial
  3. Review
  4. Article
  5. Plasma potassium concentration and cardiac repolarisation markers, TEuropean journal of applied physiology · 2022
    Article
  6. Observational
  7. Is myocardial repolarization duration associated with repolarization heterogeneity?Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tanveer A BhuiyanDepartment of Health Science and Technology, Aalborg University, Frederik Bajers vej-7 C1, 9220, Aalborg, Denmark. tb@hst.aau.dk.
Claus GraffDepartment of Health Science and Technology, Aalborg University, Frederik Bajers vej-7 C1, 9220, Aalborg, Denmark.
Jørgen K KantersLaboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jimmi NielsenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Jacob MelgaardDepartment of Health Science and Technology, Aalborg University, Frederik Bajers vej-7 C1, 9220, Aalborg, Denmark.
Jørgen MatzGlobal Pharmacovigilance, H. Lundbeck A/S, Copenhagen, Denmark.
Egon ToftDepartment of Health Science and Technology, Aalborg University, Frederik Bajers vej-7 C1, 9220, Aalborg, Denmark.
Johannes J StruijkDepartment of Health Science and Technology, Aalborg University, Frederik Bajers vej-7 C1, 9220, Aalborg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe T-peak to T-end (TpTe) interval has been suggested as an index of transmural dispersion and as a marker of drug-induced abnormal repolarization. In this study, we investigate the relation between TpTe and the QT interval.

methodsElectrocardiograms (ECGs) from five different drugs (sotalol, sertindole, moxifloxacin, nalmefene, and Lu 38-135) and from a placebo group were analyzed. Semi-automatic measurements of T-peak, T-end, and QRS onset were obtained. The TpTe/QT ratio was calculated to investigate the proportional relationship of QT and TpTe.

resultsAlthough a significant increase of both TpTe and QT from baseline is apparent with QT-prolonging drugs, the TpTe/QT ratio remained the same at baseline and after drug administration, thus indicating that prolongation of TpTe is just a fractional part of total QT prolongation. In the presence of notched or flattened T-waves, the uncertainty associated with measurement of the TpTe interval increases. The errors in TpTe for individual subjects may be substantial, thus complicating the use of TpTe for follow-up of individuals.

conclusionsThe duration of the QT interval and TpTe are closely related. Drugs appear to prolong the TpTe interval as a predictable fraction of the total QT prolongation.

Indexed as

AdultBiomarkersClinical Trials as TopicDihydropyridinesElectrocardiographyFemaleFluoroquinolonesHumansImidazolesIndolesMaleMoxifloxacinNaltrexonePharmaceutical PreparationsSotalol3-(1-(2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl)-3,6-dihydro-2H-pyridin-4-yl)-6-chloro-1H-indoleBiomarkersDihydropyridinesFluoroquinolonesImidazolesIndolesMoxifloxacinnalmefeneNaltrexonePharmaceutical PreparationssertindoleSotalol

Identifiers

PMID26410545

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.