Evidence map›Paper›PMID 26410136›Full record

ReviewCritical care clinics2015

Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury.

Trung C Nguyen, Miguel A Cruz, Joseph A Carcillo

Abstract readReview
In one paragraph

Review in Critical care clinics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  15. Review
  16. A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Trung C NguyenSection of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Center for Translational Research on Inflammatory Diseases (CTRID), Michael DeBakey VA Medical Center, Houston, TX 77030, USA. Electronic address: tcnguyen@texaschildrenshospital.org.
Miguel A CruzDepartment of Medicine, Baylor College of Medicine, Center for Translational Research on Inflammatory Diseases (CTRID), Michael DeBakey VA Medical Center, Houston, TX 77030, USA.
Joseph A CarcilloDepartment of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Funding

Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure RenewalR01GM108618 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOSEPH A CARCILLO · 2014 to 2026
$5.4M
Microvascular Thrombosis in systemic inflammationR01GM112806 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI CRUZ, MIGUEL ANGEL, NGUYEN, TRUNG CHANH · 2014 to 2022
$3.0M
Nanobind Hierarchical Silica Lamella for High Molecular Weight DNA ExtractionR44GM109618 · NIGMS · CIRCULOMICS, INC. · PI LIU, KELVIN, WANG, TZA-HUEI JEFF · 2015 to 2016
$1.5M
High Integrity and High Yield DNA Extraction Using a Nanostructured SurfaceR43GM109618 · NIGMS · CIRCULOMICS, INC. · PI LIU, KELVIN, WANG, TZA-HUEI JEFF · 2014 to 2014
$175k
NIGMS NIH HHS R01 GM108618NIGMS NIH HHS R01 GM112806NIGMS NIH HHS R43 GM109618NIGMS NIH HHS R44 GM109618
6 · The paper itself

Abstract

Thrombocytopenia-associated multiple organ failure (TAMOF) is a clinical phenotype that encompasses a spectrum of syndromes associated with disseminated microvascular thromboses, such as the thrombotic microangiopathies thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) and disseminated intravascular coagulation (DIC). Autopsies findings in TTP, HUS, or DIC reveal specific findings that can differentiate these 3 entities. Von Willebrand factor and ADAMTS-13 play a central role in TTP. Shiga toxins and the complement pathway are vital in the development of HUS. Tissue factor is the major protease that drives the pathology of DIC. Acute kidney injury (AKI) is a common feature in patients with TAMOF.

Indexed as

Acute Kidney InjuryADAM ProteinsADAMTS13 ProteinAntibodies, Monoclonal, HumanizedComplement Inactivating AgentsComplement System ProteinsDisseminated Intravascular CoagulationHemolytic-Uremic SyndromeHumansMultiple Organ FailurePurpura, Thrombotic ThrombocytopenicShiga ToxinsThromboplastinvon Willebrand FactorADAM ProteinsADAMTS13 ProteinADAMTS13 protein, humanAntibodies, Monoclonal, HumanizedComplement Inactivating AgentsComplement System ProteinseculizumabShiga ToxinsThromboplastinvon Willebrand FactorADAMTS-13AKIDICHUSPlateletTAMOFTTPVWF

Identifiers

PMID26410136
PMCPMC5281060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.