Evidence map›Paper›PMID 26409888›Full record

SynthesisJournal of neuro-oncology2016

Predictors of recurrence in the management of chordoid meningioma.

Winward Choy, Leonel Ampie, Jonathan B Lamano, Kartik Kesavabhotla, Qinwen Mao, Andrew T Parsa, Orin Bloch

Erratum issuedOpen access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The medial transorbital approach in cranioendoscopic skull base tumor resections for locally advanced tumors.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Primary Pulmonary Chordoid Meningioma.The Korean journal of thoracic and cardiovascular surgery · 2018
    Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Winward ChoyDepartment of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
Leonel AmpieDepartment of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
Jonathan B LamanoDepartment of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
Kartik KesavabhotlaDepartment of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
Qinwen MaoDepartment of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Andrew T ParsaDepartment of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA.
Orin BlochDepartment of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St Clair St, Suite 2210, Chicago, IL, 60611-2911, USA. orin.bloch@northwestern.edu.
Northwestern University · USNeurological Surgery · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA060553NIGMS NIH HHS T32 GM008152
6 · The paper itself

Abstract

Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not established given the paucity of published experience. To identify prognostic factors for recurrence following resection, the authors conducted the largest systematic review of CMs to date. A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science utilizing the search terms "chordoid" AND "meningioma" was performed to identify all reports of pathologically confirmed intracranial CMs. A total of 221 patients were included, comprising 120 females and 101 males. Mean age, MIB-1/Ki67, and tumor size was 45.5 years, 4.3% (range 0.1-26.6%), and 4.1 cm (range 0.8-10 cm), respectively. 5-, and 10- year progression free survival was 67.5 and 54.4%, respectively. Gross total resection (GTR) and subtotal resection was achieved in 172 and 48 patients, respectively. Adjuvant radiotherapy (RT) was given to 30 patients. Multivariate analysis found GTR was strongly correlated with decreased recurrence rates (HR 0.04, p = <0.0001), while higher MIB-1 labeling index (≥5 vs <5%) was associated with increased recurrence (HR 7.08; p = 0.016). Adjuvant RT, age, gender, and tumor location were not associated with recurrence. GTR resection is the strongest predictor of tumor control, and should be the goal to minimize local progression. Additionally, higher MIB-1 labeling was associated with increased rates of tumor recurrence. Tumors that are subtotally resected or demonstrate higher MIB-1 are at greater recurrence and warrant consideration for RT and close long term follow up.

Indexed as

AdultChoroidDatabases, BibliographicFemaleHumansMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeoplasm Recurrence, LocalPredictive Value of TestsTreatment OutcomeAtypicalChordoidMeningiomaRadiation therapySurgery

Identifiers

PMID26409888
PMCPMC4684776
OpenAlexW2149794835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.