SynthesisThe Cochrane database of systematic reviews2015
Antimicrobial-impregnated central venous catheters for prevention of catheter-related bloodstream infection in newborn infants.
Synthesis in The Cochrane database of systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- [Clinical practice guideline for point-of-care ultrasound-guided peripherally inserted central catheter placement in neonates (2026)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Guideline
- Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Early planned removal of umbilical venous catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2017Pooled it
- Early removal versus expectant management of central venous catheters in neonates with bloodstream infection.The Cochrane database of systematic reviews · 2016Pooled it
- Antimicrobial-impregnated central venous catheters for preventing neonatal bloodstream infection: the PREVAIL RCT.Health technology assessment (Winchester, England) · 2020Trial
- Chinese guideline for the prevention and control of complications associated to umbilical venous catheterization in neonates (2025).Pediatric investigation · 2026Article
- Mortality risk factors in actively resuscitated 22-week preterm infants: a case-control study focusing on NEC and maternal hospitalization.BMC pediatrics · 2025Article
- Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates.Frontiers in pediatrics · 2023Article
- Does the antimicrobial-impregnated peripherally inserted central catheter decrease the CLABSI rate in neonates? Results from a retrospective cohort study.Frontiers in pediatrics · 2022Article
- Umbilical Venous Catheter Update: A Narrative Review Including Ultrasound and Training.Frontiers in pediatrics · 2021Review
- Discovery of hemocompatible bacterial biofilm-resistant copolymers.Biomaterials · 2020Article
- Rapid Emergence of Multidrug-Resistance among Gram Negative Isolates at a Tertiary Pediatric and Maternity Hospital in Ulaanbaatar, Mongolia.Central Asian journal of global health · 2020Article
- The Usefulness of Microalgae Compounds for Preventing Biofilm Infections.Antibiotics (Basel, Switzerland) · 2019Review
- Turkish Neonatal Society guideline on neonatal infections-diagnosis and treatment.Turk pediatri arsivi · 2018Article
- Cost-Effectiveness of Pediatric Central Venous Catheters in the UK: A Secondary Publication from the CATCH Clinical Trial.Frontiers in pharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral venous catheter-related bloodstream infection is an important cause of mortality and morbidity in newborn infants cared for in neonatal units. Potential strategies to prevent these infections include the use of central venous catheters impregnated with antimicrobial agents.
objectivesTo determine the effect of antimicrobial-impregnated central venous catheters in preventing catheter-related bloodstream infection in newborn infants. SEARCH
methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL 2015, Issue 8), MEDLINE (1966 to September 2015), EMBASE (1980 to September 2015), CINAHL (1982 to September 2015), conference proceedings and previous reviews. SELECTION CRITERIA: Randomised or quasi-randomised controlled trials comparing central venous catheters impregnated or coated with any antibiotic or antiseptic versus central venous catheters without antibiotic or antiseptic coating or impregnation in newborn infants. DATA COLLECTION AND ANALYSIS: We extracted data using the standard methods of the Cochrane Neonatal Group, with independent evaluation of risk of bias and data extraction by two review authors. MAIN
resultsWe found only one small trial (N = 98). This trial found that silver zeolite-impregnated umbilical venous catheters reduced the incidence of bloodstream infection in very preterm infants (risk ratio 0.11, 95% confidence interval 0.01 to 0.87; risk difference -0.17, 95% CI -0.30 to -0.04; number needed to treat for benefit 6, 95% CI 3 to 25]. AUTHORS'
conclusionsAlthough the data from one small trial indicates that antimicrobial-impregnated central venous catheters might prevent catheter-related bloodstream infection in newborn infants, the available evidence is insufficient to guide clinical practice. A large, simple and pragmatic randomised controlled trial is needed to resolve on-going uncertainty.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.