Evidence map›Paper›PMID 26409568›Full record

ArticleNeuro-oncology2016

Smoking and adult glioma: a population-based case-control study in China.

Lei Hou, Jingmei Jiang, Boqi Liu, Wei Han, Yanping Wu, Xiaonong Zou, Philip C Nasca, Fang Xue, Yuanli Chen, Biao Zhang and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Assessment of the Type and Degree of Genomic Instability in Gliomas.International journal of molecular sciences · 2026
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  8. The Influence of Gene Aberrations on Survival in ResectedCurrent oncology (Toronto, Ont.) · 2021
    Article
  9. α9-Containing Nicotinic Receptors in Cancer.Frontiers in cellular neuroscience · 2021
    Review
  10. Article
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  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Lei HouDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Jingmei JiangDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Boqi LiuDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Wei HanDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Yanping WuDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Xiaonong ZouDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Philip C NascaDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Fang XueDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Yuanli ChenDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Biao ZhangDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Haiyu PangDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Yuyan WangDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Zixing WangDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Junyao LiDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China (L.H., J.J., W.H., F.X., B.Z., H.P., Y.W., Z.W.); Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (B.L., Y.W., X.Z., Y.C., J.L.); School of Public Health, State University of New York, Albany, New York (P.C.N.).
Chinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity at Albany, State University of New York · US

Funding

Medical Research Council
6 · The paper itself

Abstract

backgroundSmoking increases the risk of numerous cancers; however, an association of smoking with adult gliomas has not been found in a population.

methodsThis case-control study included 4556 glioma cases (ICD-9 code 191.0-191.9) aged ≥ 30 years and 9112 controls from a national survey of smoking and mortality in China in 1989-1991. Controls from 325 255 surviving spouses of all-cause deaths were randomly assigned to cases in each of 103 areas according to sex and age groups at a ratio of 2:1. Smoking information was ascertained retrospectively by interviewing surviving spouses.

resultsAfter adjustment for confounders, smoking increased the risk of glioma deaths by 11% (odds ratio [OR] = 1.11; 95% confidence interval [CI]: 1.03-1.21). Compared with non-smokers; the increased risk was 9% (OR = 1.09; 95% CI: 0.99-1.20) in men and 16% (OR = 1.16; 95% CI: 1.00-1.36) in women. The risk increased with age and doses. For individuals aged ≥ 50 years, smoking was associated with higher risk of glioma death by 25% (OR = 1.25; 95% CI: 1.15-1.38); this increased risk for smokers who smoked ≥ 20 cigarettes daily for ≥ 30 years was 53% (OR = 1.53; 95% CI: 1.34-1.74). There were similar findings in both men and women and with either pathology-based or non-pathology-based comparisons.

conclusionsThis study indicates that smoking is associated with glioma deaths in the Chinese population. Long-term heavy smoking could be a factor for risk stratification in individuals attending brain tumor clinics.

Indexed as

AdultBrain NeoplasmsCase-Control StudiesChinaFemaleGliomaHumansMaleMiddle AgedRisk FactorsSmokingcase-controldeathepidemiological designgliomasmoking

Identifiers

PMID26409568
PMCPMC4677414
OpenAlexW2211503338

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.