Evidence map›Paper›PMID 26409567›Full record

ArticleNeuro-oncology2016

Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling.

Julia V Cockle, Karishma Rajani, Shane Zaidi, Timothy Kottke, Jill Thompson, Rosa Maria Diaz, Kevin Shim, Tim Peterson, Ian F Parney, Susan Short and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial.Molecular therapy : the journal of the American Society of Gene Therapy · 2017
    Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. A review of glioblastoma immunotherapy.Journal of neuro-oncology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Julia V CockleLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Karishma RajaniLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Shane ZaidiLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Timothy KottkeLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Jill ThompsonLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Rosa Maria DiazLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Kevin ShimLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Tim PetersonLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Ian F ParneyLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Susan ShortLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Peter SelbyLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Elizabeth IlettLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Alan MelcherLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
Richard VileLeeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds, UK (J.V.C., S.S., P.S., E.I., A.M., R.V.); Department of Immunology, Mayo Clinic, Rochester, Minnesota (K.R., S.Z., T.K., J.T., R.M.D., K.S., R.V.); Division of Cancer Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK (S.Z., R.V.); Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota (T.P., I.F.P.).
University of Leeds · GBInstitute of Cancer Research · GBMayo Clinic · US

Funding

Targeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI GIANNINI, CATERINA · 2004 to 2015
$22.5M
Enhancing Therapy of Primary and Recurrent Tumors With Systemic Oncolytic VirusR01CA175386 · NCI · MAYO CLINIC ROCHESTER · PI VILE, RICHARD G. · 2014 to 2018
$1.3M
MOLECULAR STUDIES OF THE YEAST CELL CYCLE GENE CDC7F32CA008961 · NCI · UNIVERSITY OF COLORADO DENVER · PI OSTROFF, RACHEL M · 1990 to 1992
–
Department of Health RP-PG-0707-10101NCI NIH HHS CA108961NCI NIH HHS R011CA08961-03NCI NIH HHS R01 CA175386NCI NIH HHS R01 CA175386-01
6 · The paper itself

Abstract

backgroundSystemic delivery of a complementary cDNA library expressed from the vesicular stomatitis virus (VSV) treats tumors by vaccinating against a wide range of tumor associated antigens (TAAs). For subcutaneous B16 melanomas, therapy was achieved using a specific combination of self-TAAs (neuroblastoma-Ras, cytochrome c, and tyrosinase-related protein 1) expressed from VSV. However, for intracranial B16 tumors, a different combination was therapeutic (consisting of VSV-expressed hypoxia-inducible factor [HIF]-2α, Sox-10, c-Myc, and tyrosinase-related protein 1). Therefore, we tested the hypothesis that tumors of different histological types growing in the brain share a common immunogenic signature which can be exploited for immunotherapy.

methodsSyngeneic tumors, including GL261 gliomas, in the brains of immune competent mice were analyzed for their antigenic profiles or were treated with systemic viroimmunotherapy.

resultsSeveral different histological types of tumors growing intracranially, as well as freshly resected human brain tumor explants, expressed a HIF-2α(Hi) phenotype imposed by brain-derived CD11b+ cells. This location-specific antigen expression was exploited therapeutically against intracranial GL261 gliomas using systemically delivered VSV expressing HIF-2α, Sox-10, and c-Myc. Viroimmunotherapy was enhanced by immune checkpoint inhibitors, associated with the de-repression of antitumor T-helper cell type 1 (Th1) interferon-γ and Th17 T cell responses.

conclusionsSince different tumor types growing in the same location in the brain share a location-specific phenotype, we suggest that antigen-specific immunotherapies should be based upon expression of both histological type-specific tumor antigens and location-specific antigens. Our findings support clinical application of VSV-TAA therapy with checkpoint inhibition for aggressive brain tumors and highlight the importance of the intracranial microenvironment in sculpting a location-specific profile of tumor antigen expression.

Indexed as

ImmunotherapyOncolytic VirotherapyAnimalsAntigens, NeoplasmBrain NeoplasmsCell CycleCell Cycle CheckpointsCombined Modality TherapyEnzyme-Linked Immunosorbent AssayFlow CytometryGliomaHumansInterferon-gammaMaleMelanoma, ExperimentalMiceAntigens, NeoplasmInterferon-gammacancer immunotherapycheckpoint inhibitorgliomaoncolytic virusvesicular stomatitis virus

Identifiers

PMID26409567
PMCPMC4799678
OpenAlexW2262102254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.