Trial reportRestorative neurology and neuroscience2015
Anodal direct current stimulation in the healthy aged: Effects determined by the hemisphere stimulated.
Trial report in Restorative neurology and neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of Transcranial Direct Current Stimulation on Upper-Limb Motor Performance in Healthy Adults: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- Laser acupuncture improves cortical excitability and behavioural performance in healthy individuals: a randomized controlled trial.BMC complementary medicine and therapies · 2026Trial
- The effects of concurrent bilateral anodal tDCS of primary motor cortex and cerebellum on corticospinal excitability: a randomized, double-blind sham-controlled study.Brain structure & function · 2022Trial
- Effect of Anodal Transcranial Direct Current Stimulation of the Motor Cortex on Elbow Flexor Muscle Strength in the Very Old.Journal of geriatric physical therapy (2001)Trial
- Brain responses to different action observation paradigms and assessing transferable cross-paradigm decoding.Journal of neuroengineering and rehabilitation · 2026Article
- tDCS over the primary motor cortex contralateral to the trained hand enhances cross-limb transfer in older adults.Frontiers in aging neuroscience · 2022Article
- Safety and effects of transcranial direct current stimulation on hand function in preschool children with hemiplegic cerebral palsy: A pilot study.Frontiers in behavioral neuroscience · 2022Article
- [Effects of parameters selection with transcranial direct current stimulation based on real head model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Can Transcranial Direct Current Stimulation Enhance Functionality in Older Adults? A Systematic Review.Journal of clinical medicine · 2021Review
- Ten minutes of transcranial static magnetic field stimulation does not reliably modulate motor cortex excitability.PloS one · 2020Article
- The Effects of Transcranial Electrical Stimulation on Human Motor Functions: A Comprehensive Review of Functional Neuroimaging Studies.Frontiers in neuroscience · 2020Review
- Reliability and Variability of tDCS Induced Changes in the Lower Limb Motor Cortex.Brain sciences · 2016Article
- No Effect of Anodal Transcranial Direct Current Stimulation Over the Motor Cortex on Response-Related ERPs during a Conflict Task.Frontiers in human neuroscience · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeResearch popularity and scope for the application of transcranial direct current stimulation have been steadily increasing yet many fundamental questions remain unanswered. We sought to determine if anodal stimulation of either hemisphere leads to improved performance of the contralateral hand and/or altered function of the ipsilateral hand, or affects movement preparation, in older subjects.
methodIn this cross-over, double blind, sham controlled study, 34 healthy aged participants (age range 40- 86) were randomised to receive 20 minutes of stimulation to either the dominant or non-dominant motor cortex. The primary outcome was functional performance of both upper limbs measured by the Jebsen Taylor Test and hand grip strength. Additionally, we measured motor preparation using electrophysiological (EEG) recordings.
resultsAnodal stimulation resulted in statistically significantly improved performance of the non-dominant hand (p < 0.01) but did not produce significant changes in the dominant hand on any measure (p > 0.05). This effect occurred irrespective of the hemisphere stimulated. Stimulation did not produce significant effects on measures of gross function, grip strength, reaction times, or electrophysiological measures on the EEG data.
conclusionThis study demonstrated that the hemispheres respond differently to anodal stimulation and the response appears to be task specific but not mediated by age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.