ArticleRestorative neurology and neuroscience2015
Visuo-motor integration in unresponsive wakefulness syndrome: A piece of the puzzle towards consciousness detection?
Article in Restorative neurology and neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Dysfunctional connectivity as a neurophysiologic mechanism of disorders of consciousness: a systematic review.Frontiers in neuroscience · 2023Review
- Towards New Diagnostic Approaches in Disorders of Consciousness: A Proof of Concept Study on the Promising Use of Imagery Visuomotor Task.Brain sciences · 2020Article
- Toward Improving Diagnostic Strategies in Chronic Disorders of Consciousness: An Overview on the (Re-)Emergent Role of Neurophysiology.Brain sciences · 2020Article
- Diagnosing Disorder of Consciousness: The Opening of Pandora's Box!Innovations in clinical neuroscienceArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe unresponsive wakefulness syndrome (UWS) is characterized by either a profound unawareness or an impairment of large-scale cortico/subcortical connectivity. Nevertheless, some individuals with UWS could show residual markers of consciousness and cognition. In this study, we applied an electrophysiological approach aimed to identify the residual visuomotor connectivity patterns that are thought to be linked to awareness, in patients with chronic disorder of consciousness (DOC).
methodsWe measured some markers of visuomotor and premotor-motor integration in 14 patients affected by DOC, before and after the application of transcranial direct current stimulation, delivered over the dorsolateral prefrontal cortex and the parieto-occipital area, paired to transorbital alterning current stimulation.
resultsOur protocol induced a potentiation of the electrophysiological markers of visuomotor and premotor-motor connectivity, paired to a clinical improvement, in all of the patients with minimally conscious state and in one individual affected by UWS.
conclusionsOur protocol could be a promising approach to potentiate the functional connectivity within large-scale visuomotor networks, thus allowing identifying the patients suffering from a functional locked-in syndrome (i.e. individuals showing an extreme behavioral motor dysfunction although with somehow preserved cognitive functions that can be identified only through para-clinical tests) within individuals with UWS.
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