Evidence map›Paper›PMID 26409344›Full record

ReviewNeuroscience and biobehavioral reviews2015

Neuroimaging of Parkinson's disease: Expanding views.

Carol P Weingarten, Mark H Sundman, Patrick Hickey, Nan-kuei Chen

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 157 citations in OpenAlex.

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  6. Review
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  14. Prediction of Parkinson's disease by transcranial sonography-based deep learning.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
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  19. Timing Patterns in the Extended Basal Ganglia System.Advances in experimental medicine and biology · 2024
    Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carol P WeingartenDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, United States. Electronic address: carol.weingarten@duke.edu.
Mark H SundmanBrain Imaging and Analysis Center, Duke University Medical Center, United States.
Patrick HickeyDepartment of Neurology, Duke University School of Medicine, United States.
Nan-kuei ChenBrain Imaging and Analysis Center, Duke University Medical Center, United States; Department of Radiology, Duke University School of Medicine, United States.
Duke University · USDuke Medical Center · US

Funding

Imaging of Intrinsic Connectivity NetworksR01NS074045 · NINDS · DUKE UNIVERSITY · PI CHEN, NAN-KUEI · 2011 to 2015
$1.5M
NINDS NIH HHS R01 NS074045NINDS NIH HHS R01NS074045
6 · The paper itself

Abstract

Advances in molecular and structural and functional neuroimaging are rapidly expanding the complexity of neurobiological understanding of Parkinson's disease (PD). This review article begins with an introduction to PD neurobiology as a foundation for interpreting neuroimaging findings that may further lead to more integrated and comprehensive understanding of PD. Diverse areas of PD neuroimaging are then reviewed and summarized, including positron emission tomography, single photon emission computed tomography, magnetic resonance spectroscopy and imaging, transcranial sonography, magnetoencephalography, and multimodal imaging, with focus on human studies published over the last five years. These included studies on differential diagnosis, co-morbidity, genetic and prodromal PD, and treatments from L-DOPA to brain stimulation approaches, transplantation and gene therapies. Overall, neuroimaging has shown that PD is a neurodegenerative disorder involving many neurotransmitters, brain regions, structural and functional connections, and neurocognitive systems. A broad neurobiological understanding of PD will be essential for translational efforts to develop better treatments and preventive strategies. Many questions remain and we conclude with some suggestions for future directions of neuroimaging of PD.

Indexed as

NeuroimagingAnimalsBrainHumansMagnetoencephalographyNerve NetNeurotransmitter AgentsParkinson DiseaseNeurotransmitter AgentsBrain imagingDiffusion tensor imagingDTIfMRIFunctional connectivityMagnetic resonance imagingMEGMRIMRSNeuroimagingParkinson's diseasePETPositron emission tomographySPECTTCS

Identifiers

PMID26409344
PMCPMC4763948
OpenAlexW2163358930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.