Evidence map›Paper›PMID 26409286›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015

Translating the Tuberculosis Research Agenda: Much Accomplished, but Much More to Be Done.

Marco Schito, Markus Maeurer, Peter Kim, Debra Hanna, Alimuddin Zumla

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Design, synthesis, andMedChemComm · 2019
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marco SchitoCritical Path to TB Drug Regimens, Critical Path Institute, Tucson, Arizona.
Markus MaeurerTherapeutic Immunology Division, Department of Laboratory Medicine, Karolinska Institutet Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden.
Peter KimDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Debra HannaCritical Path to TB Drug Regimens, Critical Path Institute, Tucson, Arizona.
Alimuddin ZumlaDivision of Infection and Immunity Center for Clinical Microbiology, University College London Biomedical Research Centre at University College Hospitals NHS Trust, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the availability of effective diagnostics and curative treatment regimens for tuberculosis, millions of people die each year of this disease. The steady global increase in the number of tuberculosis cases caused by multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis are of major concern, especially in light of the thin tuberculosis drug pipeline. New tuberculosis drugs are undergoing clinical evaluation, and renewed hope comes from fresh approaches to improve treatment outcomes using a range of adjunct host-directed cellular and repurposed drug therapies. Current efforts in developing second-generation and new rapid point-of-care diagnostic assays take advantage of recent genetic and molecular advances. Slow progress in the development of prophylactic and therapeutic vaccines requires increased funding for basic as well as translational research. Although major challenges remain, these can be overcome by cementing our resolve, raising advocacy, bolstering global funder investments, and leveraging more effective collaborations through equitable public-private partnerships.

Indexed as

Antitubercular AgentsBiomedical ResearchMycobacterium tuberculosisTuberculosisDrug DiscoveryGlobal HealthHealth ResourcesHumansMolecular Diagnostic TechniquesPoint-of-Care SystemsTuberculosis, Multidrug-ResistantAntitubercular Agentsdrug resistancenew treatment regimensresearchresource-limited settingstuberculosis

Identifiers

PMID26409286
PMCPMC4583569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.