Evidence map›Paper›PMID 26409281›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015

Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update.

Stephen M Graham, Luis E Cuevas, Patrick Jean-Philippe, Renee Browning, Martina Casenghi, Anne K Detjen, Devasena Gnanashanmugam, Anneke C Hesseling, Beate Kampmann, Anna Mandalakas and 6 more

2 registry-linked trialsAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 209 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05989802 narecruitingnot on this mapstarted 2024, after this paper: background citation

Rapid Research in Diagnostics Development for Tuberculosis Network (R2D2 Kids) and Assessing Diagnostics At Point-of-care for Tuberculosis in Children (ADAPT for Kids)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2026Enrolled2,100ConditionsTuberculosis, Diagnostics, Global HealthArmsOral swab molecular testing, Automated Cough Sound Analysis, Automated Lung Sound Analysis, Chest X Ray Computer Aided Detection
NCT06875336 recruitingnot on this mapstarted 2023, after this paper: background citation

A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis

TypeobservationalSponsorUniversity of CologneRan2023 to 2025Enrolled150ConditionsExtrapulmonary TuberculosisArmsbiomarker analysis
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Screening tests for active pulmonary tuberculosis in children.The Cochrane database of systematic reviews · 2021
    Pooled it
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  15. Trial
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  17. Approaches and processes for paediatric chest X-ray classification used in the SHINE TB treatment-shortening trial.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2024
    Trial
  18. Clinical Outcomes in Children With Human Immunodeficiency Virus Treated for Nonsevere Tuberculosis in the SHINE Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Trial
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  20. Trial

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stephen M GrahamCentre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Australia International Union Against Tuberculosis and Lung Disease, Paris, France Burnet Institute, Melbourne, Australia.
Luis E CuevasDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom.
Patrick Jean-PhilippeHenry M. Jackson Foundation.
Renee BrowningDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Martina CasenghiMédicins Sans Frontières, Geneva, Switzerland.
Anne K DetjenInternational Union Against Tuberculosis and Lung Disease, Paris, France.
Devasena GnanashanmugamDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Anneke C HesselingDesmond Tutu Tuberculosis Centre, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Beate KampmannDepartment of Paediatrics, Imperial College London, United Kingdom Vaccinology Theme, MRC Unit, The Gambia.
Anna MandalakasDepartment of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston.
Ben J MaraisMarie Bashir Institute for Infectious Diseases and Biosecurity) and the Sydney Emerging Infectious Diseases and Biosecurity Institute and The Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Australia.
Marco SchitoHenry M. Jackson Foundation.
Hans M L SpiegelHenry M. Jackson Foundation.
Jeffrey R StarkeDepartment of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston.
Carol WorrellEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland.
Heather J ZarDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, MRC Unit on Child and Adolescent Health, University of Cape Town, South Africa.

Funding

Stellenbosch University Clinical Trial Unit, Cape Town, South AfricaUM1AI069521 · NIAID · STELLENBOSCH UNIVERSITY · PI Shaun Barnabas, Anneke Catharina Hesseling · 2012 to 2026
$21.5M
Department of Health SRF-2009-02-07Medical Research Council MC_EX_MR/K011944/1Medical Research Council MC_UP_A900_1122NIAID NIH HHS HHSN272200800014CNIAID NIH HHS UM1 AI069521
6 · The paper itself

Abstract

Consensus case definitions for childhood tuberculosis have been proposed by an international expert panel, aiming to standardize the reporting of cases in research focusing on the diagnosis of intrathoracic tuberculosis in children. These definitions are intended for tuberculosis diagnostic evaluation studies of symptomatic children with clinical suspicion of intrathoracic tuberculosis, and were not intended to predefine inclusion criteria into such studies. Feedback from researchers suggested that further clarification was required and that these case definitions could be further improved. Particular concerns were the perceived complexity and overlap of some case definitions, as well as the potential exclusion of children with acute onset of symptoms or less severe disease. The updated case definitions proposed here incorporate a number of key changes that aim to reduce complexity and improve research performance, while maintaining the original focus on symptomatic children suspected of having intrathoracic tuberculosis. The changes proposed should enhance harmonized classification for intrathoracic tuberculosis disease in children across studies, resulting in greater comparability and the much-needed ability to pool study results.

Indexed as

ChildChild, PreschoolHumansMaleReference StandardsThoraxTuberculosisTuberculosis, Pulmonarychildhood tuberculosistuberculosis case definitionstuberculosis classificationtuberculosis diagnosis

Identifiers

PMID26409281
PMCPMC4583568

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.