ReviewBritish journal of clinical pharmacology2016
Activated charcoal for acute overdose: a reappraisal.
Review in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of Taste Additives on the Palatability of Activated Charcoal: a Systematic Review.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023Pooled it
- First aid interventions by laypeople for acute oral poisoning.The Cochrane database of systematic reviews · 2018Pooled it
- Effect of Activated Charcoal on Rivaroxaban Complex Absorption.Clinical pharmacokinetics · 2017Trial
- Calcium montmorillonite clay: a clinically oriented narrative review of emerging perioperative and supportive applications.Annals of translational medicine · 2026Review
- POCUS for Detection of Esophageal and Gastric Foreign Bodies.POCUS journal · 2025Article
- Article
- Prophylactic Oral Application of Activated Charcoal Mitigates Acute Campylobacteriosis in Human Gut Microbiota-Associated IL-10Biomolecules · 2024Article
- Should Activated Charcoal Powder can be Considered as an Over-The-Counter Medication for Acute Poisoning Cases?International journal of preventive medicine · 2024Article
- Natural American Spirit launches 'Sky', the brand's first commercial organic cigarette with a charcoal filter.Tobacco control · 2023Article
- [Patients requiring ICU treatment for acute poisoning-a 20-year single-center retrospective : Acute poisoning in intensive care].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2023Article
- Relative dentin and enamel abrasivity of charcoal toothpastes.International journal of dental hygiene · 2023Article
- Uremic pruritus: pathophysiology, clinical presentation, and treatments.Kidney research and clinical practice · 2023Article
- Effect of 16% Carbamide Peroxide and Activated-Charcoal-Based Whitening Toothpaste on Enamel Surface Roughness in Bovine Teeth: An In Vitro Study.Biomedicines · 2022Article
- Recent Advances in Mesoporous Materials and Their Biomedical Applications.International journal of molecular sciences · 2022Article
- Activated Carbon for Drug Delivery from Composite Biomaterials: The Effect of Grinding on Sirolimus Binding and Release.Pharmaceutics · 2022Article
- Microbial approaches for the assessment of toothpaste efficacy against oral species: A method comparison.MicrobiologyOpen · 2022Article
- A 53-year-old woman with a suspected drug overdose.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Evolution of porous materials from ancient remedies to modern frameworks.Communications chemistry · 2021Article
- Disease-Alleviating Effects of Peroral Activated Charcoal Treatment in Acute Murine Campylobacteriosis.Microorganisms · 2021Article
- The Individualized Management Approach for Acute Poisoning.Advances in pharmacological and pharmaceutical sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sometimes mistakenly characterized as a 'universal antidote,' activated charcoal (AC) is the most frequently employed method of gastrointestinal decontamination in the developed world. Typically administered as a single dose (SDAC), its tremendous surface area permits the binding of many drugs and toxins in the gastrointestinal lumen, reducing their systemic absorption. Like other decontamination procedures, the utility of SDAC attenuates with time, and, although generally safe, it is not free of risk. A large body of evidence demonstrates that SDAC can reduce the absorption of drugs and xenobiotics but most such studies involve volunteers and have little generalizability to clinical practice. Few rigorous clinical trials of SDAC have been conducted, and none validate or refute its utility in those patients who are intuitively most likely to benefit. Over the past decade, a growing body of observational data have demonstrated that SDAC can elicit substantial reductions in drug absorption in acutely poisoned patients. The challenge for clinicians rests in differentiating those patients most likely to benefit from SDAC from those in whom meaningful improvement is doubtful. This is often a difficult determination not well suited to an algorithmic approach. The present narrative review summarizes the data supporting the benefits and harms of SDAC, and offers pragmatic suggestions for clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.