ReviewBiochimica et biophysica acta2016
The role of cerebrovascular disease when there is concomitant Alzheimer disease.
Review in Biochimica et biophysica acta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- [Formula: see text]Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status.The Clinical neuropsychologist · 2017Trial
- White matter hyperintensity severity modifies gut metabolite association with cognitive outcomes.The journal of prevention of Alzheimer's disease · 2025Article
- Associations of cerebrovascular disease and Alzheimer's disease pathology with cognitive decline: Analysis of the National Alzheimer's Coordinating Center Uniform Data Set.Neurobiology of aging · 2024Article
- Exploring the neuroprotective role of physical activity in cerebral small vessel disease.Brain research · 2024Review
- Development of a monoclonal antibody specific for a calpain-generated ∆48 kDa calcineurin fragment, a marker of distressed astrocytes.Journal of neuroscience methods · 2024Article
- Cerebral artery and brain pathology correlates of antemortem cerebral artery 4D flow MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A pathway linking pulse pressure to dementia in adults with Down syndrome.Brain communications · 2024Article
- Evaluating the Diagnostic Value of Electrovestibulography (EVestG) in Alzheimer's Patients with Mixed Pathology: A Pilot Study.Medicina (Kaunas, Lithuania) · 2023Article
- Pathways linking pulse pressure to dementia in adults with Down syndrome.medRxiv : the preprint server for health sciences · 2023Article
- White matter hyperintensity, neurofilament light chain, and cognitive decline.Annals of clinical and translational neurology · 2023Article
- Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer's disease.Ageing research reviews · 2021Review
- Entorhinal Perfusion Predicts Future Memory Decline, Neurodegeneration, and White Matter Hyperintensity Progression in Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline.Neurobiology of aging · 2020Article
- Cardiorespiratory Fitness Associates with Cerebral Vessel Pulsatility in a Cohort Enriched with Risk for Alzheimer's Disease.Brain plasticity (Amsterdam, Netherlands) · 2020Article
- Vascular risk factors are associated with longitudinal changes in cerebrospinal fluid tau markers and cognition in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Additive effect of cerebral atrophy on cognition in dementia-free elderly with cerebrovascular disease.Stroke and vascular neurology · 2019Article
- White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.Alzheimer's & dementia (New York, N. Y.) · 2019Review
- Precision Aging: Applying Precision Medicine to the Field of Cognitive Aging.Frontiers in aging neuroscience · 2019Article
- Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease.Alzheimer's research & therapy · 2018Article
- "Exceptional brain aging" without Alzheimer's disease: triggers, accelerators, and the net sum game.Alzheimer's research & therapy · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cerebrovascular Pathologies (CVP) are the most common co-existent pathologies observed in conjunction with Alzheimer disease. CVP rarely exists in isolation in later life, and CVP most likely plays a supporting role, rather than a sole leading role, in the pathogenesis of dementia. Our goal is to illustrate CVP's role using neuroimaging biomarkers. First, we discuss the frequency of CVP and present data from population-based Mayo Clinic Study of Aging. Here, we used a novel metric for identifying individuals with cerebrovascular imaging abnormalities (that we designate as "V+") and present the frequency of V-/V+ in the context of absence and presence of β-amyloid elevation (designated A-/A+). Next, we discuss the contribution of CVP to neurodegeneration and use hippocampal volume loss over time in a subset of participants categorized as A-V-, A-V+, A+V-, A+V+. Lastly, we discuss the contribution of CVP to cognitive impairment and conclude with the considerations for design of future studies. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.