ArticleCerebral cortex (New York, N.Y. : 1991)2016
Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample: Role of Sex, Ethnicity, Puberty, and Alcohol Drinking.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- Volumetric segmentation in the context of posterior fossa-related pathologies: a systematic review.Neurosurgical review · 2024Pooled it
- Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis.Neuropsychology review · 2019Pooled it
- Intra-individual changes in Stroop-related activations linked to cigarette abstinence in adolescent tobacco smokers: Preliminary findings.Drug and alcohol dependence · 2016Trial
- Modality-Aware and Anatomical Vector-Quantized Autoencoding for Multimodal Brain MRI.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2026Article
- Divergent Pathways Taken in Adolescence Predict Embracing or Resisting Moderate-to-Heavy Drinking in Young Adulthood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Sex differences in the neuroimmune response following heavy, binge-like alcohol exposure in adolescent rats.Journal of neuroimmunology · 2025Article
- In vivo growth trajectories of regional brain volumes in the Wistar rat.Neurobiology of aging · 2025Article
- Socioemotional and Executive Control Mismatch in Adolescence and Risks for Initiating Drinking.JAMA network open · 2025Article
- Restrained Eating Features and Brain Morphology: A Pediatric Population-Based Study.The International journal of eating disorders · 2025Article
- Morphologic characteristics of distal intracranial arteries in relation to structural changes in the brain after chronic alcohol consumption.Scientific reports · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective.The American journal of drug and alcohol abuse · 2025Review
- More similarity than difference: Comparison of within- and between-sex variance in early adolescent brain structure.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Network topology and cannabis use following two weeks of monitored abstinence: moderation of sex and patterns of use findings.Frontiers in adolescent medicine · 2025Article
- Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.Developmental cognitive neuroscience · 2024Article
- Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women.The American journal of psychiatry · 2024Article
- More similarity than difference: comparison of within- and between-sex variance in early adolescent brain structure.Research square · 2024Article
- A longitudinal study of the relationship between alcohol-related blackouts and attenuated structural brain development.Developmental cognitive neuroscience · 2024Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 7 institutions in 2 countries.
Funding
Abstract
Brain structural development continues throughout adolescence, when experimentation with alcohol is often initiated. To parse contributions from biological and environmental factors on neurodevelopment, this study used baseline National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) magnetic resonance imaging (MRI) data, acquired in 674 adolescents meeting no/low alcohol or drug use criteria and 134 adolescents exceeding criteria. Spatial integrity of images across the 5 recruitment sites was assured by morphological scaling using Alzheimer's disease neuroimaging initiative phantom-derived volume scalar metrics. Clinical MRI readings identified structural anomalies in 11.4%. Cortical volume and thickness were smaller and white matter volumes were larger in older than in younger adolescents. Effects of sex (male > female) and ethnicity (majority > minority) were significant for volume and surface but minimal for cortical thickness. Adjusting volume and area for supratentorial volume attenuated or removed sex and ethnicity effects. That cortical thickness showed age-related decline and was unrelated to supratentorial volume is consistent with the radial unit hypothesis, suggesting a universal neural development characteristic robust to sex and ethnicity. Comparison of NCANDA with PING data revealed similar but flatter, age-related declines in cortical volumes and thickness. Smaller, thinner frontal, and temporal cortices in the exceeds-criteria than no/low-drinking group suggested untoward effects of excessive alcohol consumption on brain structural development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.