ReviewAdvanced drug delivery reviews2015
Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders.
Review in Advanced drug delivery reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 68 citations in OpenAlex.
- Tracking inflammation status for improving patient prognosis: A review of current methods, unmet clinical needs and opportunities.Biotechnology advances · 2025Review
- Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Continuous Biosensor Based on Particle Motion: How Does the Concentration Measurement Precision Depend on Time Scale?ACS sensors · 2024Article
- Calligraphy of Nanoplasmonic Bioink-Based Multiplex Immunosensor for Precision Immune Monitoring and Modulation.ACS applied materials & interfaces · 2023Article
- Photoactive hydrogels for pre-concentration, labelling, and controlled release of proteins.The Analyst · 2023Article
- A digital nanoplasmonic microarray immunosensor for multiplexed cytokine monitoring during CAR T-cell therapy from a leukemia tumor microenvironment model.Biosensors & bioelectronics · 2023Article
- Assessment of Immune Status Using Inexpensive Cytokines: A Literature Review and Learning Approaches.Sensors (Basel, Switzerland) · 2022Review
- Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide Aptamer.ACS applied materials & interfaces · 2022Article
- Continuous biomarker monitoring with single molecule resolution by measuring free particle motion.Nature communications · 2022Article
- Real-Time Monitoring of Biomolecules: Dynamic Response Limits of Affinity-Based Sensors.ACS sensors · 2022Article
- Sensing Methodology for the Rapid Monitoring of Biomolecules at Low Concentrations over Long Time Spans.ACS sensors · 2021Article
- Loneliness: An Immunometabolic Syndrome.International journal of environmental research and public health · 2021Review
- A label-free graphene-based impedimetric biosensor for real-time tracing of the cytokine storm in blood serum; suitable for screening COVID-19 patients.RSC advances · 2021Article
- Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors.Advanced healthcare materials · 2021Review
- Machine learning-based cytokine microarray digital immunoassay analysis.Biosensors & bioelectronics · 2021Article
- A digital protein microarray for COVID-19 cytokine storm monitoring.Lab on a chip · 2021Article
- Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis.Frontiers in oncology · 2021Review
- Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases.Sensors (Basel, Switzerland) · 2020Review
- Point-of-care-ready nanoscale ISFET arrays for sub-picomolar detection of cytokines in cell cultures.Analytical and bioanalytical chemistry · 2020Article
- Low-Fouling Substrates for Plasmonic Sensing of Circulating Biomarkers in Biological Fluids.Biosensors · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Systemic inflammatory disorders resulting from infection, trauma, surgery, and severe disease conditions pose serious threats to human health leading to organ dysfunction, organ failure, and mortality. The highly complex and dynamic nature of the immune system experiencing acute inflammation makes immunomodulatory therapy blocking pro-inflammatory cytokines very challenging. Successful therapy requires the ability to determine appropriate anti-cytokine drugs to be delivered at a right dose in a timely manner. Label-free micro- and nano-biosensors hold the potential to overcome the current challenges, enabling cytokine-targeted treatments to be tailored according to the immune status of an individual host with their unique cytokine biomarker detection capabilities. This review studies the recent progress in label-free cytokine biosensors, summarizes their performances and potential merits, and discusses future directions for their advancements to meet challenges towards personalized anti-cytokine drug delivery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.