ReviewAmerican journal of physiology. Lung cellular and molecular physiology2015
Influenza lung injury: mechanisms and therapeutic opportunities.
Review in American journal of physiology. Lung cellular and molecular physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Review
- Ubiquitin E3 ligase MARCH10 targets influenza hemagglutinin for ubiquitination.Cellular signalling · 2025Article
- Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein.The EMBO journal · 2022Article
- Article
- From virus to inflammation, how influenza promotes lung damage.Journal of leukocyte biology · 2021Review
- Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury.eLife · 2020Article
- Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection.Nature communications · 2019Article
- Genome-wide effect of pulmonary airway epithelial cell-specificFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Lethal avian influenza A (H5N1) virus replicates in pontomedullary chemosensitive neurons and depresses hypercapnic ventilatory response in mice.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza.F1000Research · 2019Article
- Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.Nature immunology · 2018Article
- Surviving Deadly Lung Infections: Innate Host Tolerance Mechanisms in the Pulmonary System.Frontiers in immunology · 2018Review
- Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- ATP catabolism by tissue nonspecific alkaline phosphatase contributes to development of ARDS in influenza-infected mice.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Influenza virus infection alters ion channel function of airway and alveolar cells: mechanisms and physiological sequelae.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Ion channels of the lung and their role in disease pathogenesis.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Treating the host response to emerging virus diseases: lessons learned from sepsis, pneumonia, influenza and Ebola.Annals of translational medicine · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In this Perspectives, we discuss some recent developments in the pathogenesis of acute lung injury following influenza infection, with an emphasis on promising therapeutic leads. Damage to the alveolar-capillary barrier has been quantified in mice, and agents have been identified that can help to preserve barrier integrity, such as vasculotide, angiopoietin-like 4 neutralization, and sphingosine 1-phosphate mimics. Results from studies using mesenchymal stem cells have been disappointing, despite promising data in other types of lung injury. The roles of fatty acid binding protein 5, prostaglandin E2, and the interplay between IFN-γ and STAT1 in epithelial signaling during infection have been addressed in vitro. Finally, we discuss the role of autophagy in inflammatory cytokine production and the viral life cycle and the opportunities this presents for intervention.
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