ArticleAmerican journal of physiology. Heart and circulatory physiology2015
Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes.
Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025Pooled it
- Ambient Temperature Preservation Supports Recovery of Beating Capacity in Human Cardiac Organoids After Exposure to Simulated Space Stressors.International journal of molecular sciences · 2026Article
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading.Life sciences in space research · 2025Article
- Cardiovascular effects of long-duration space flight.Health science reports · 2024Review
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model.Life sciences in space research · 2023Article
- Drug Discovery Targeting Post-Translational Modifications in Response to DNA Damages Induced by Space Radiation.International journal of molecular sciences · 2023Review
- Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart.Life (Basel, Switzerland) · 2023Article
- Countermeasures for Maintaining Cardiovascular Health in Space Missions.Current cardiology reviews · 2023Article
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice.Life sciences in space research · 2022Article
- Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart.International journal of molecular sciences · 2021Article
- Article
- Ionizing radiation-induced circulatory and metabolic diseases.Environment international · 2021Review
- Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem.Frontiers in cardiovascular medicine · 2021Review
- Microgravity × Radiation: A Space Mechanobiology Approach Toward Cardiovascular Function and Disease.Frontiers in cell and developmental biology · 2021Review
- Emerging Role of Exosomal Long Non-coding RNAs in Spaceflight-Associated Risks in Astronauts.Frontiers in genetics · 2021Article
- Long-term spaceflight and the cardiovascular system.Precision clinical medicine · 2020Article
- Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats.Life sciences in space research · 2020Article
- Article
- NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models.Cancers · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
There are 160,000 cancer patients worldwide treated with particle radiotherapy (RT). With the advent of proton, and high (H) charge (Z) and energy (E) HZE ionizing particle RT, the cardiovascular diseases risk estimates are uncertain. In addition, future deep space exploratory-type missions will expose humans to unknown but low doses of particle irradiation (IR). We examined molecular responses using transcriptome profiling in left ventricular murine cardiomyocytes isolated from mice that were exposed to 90 cGy, 1 GeV proton ((1)H) and 15 cGy, 1 GeV/nucleon iron ((56)Fe) over 28 days after exposure. Unsupervised clustering analysis of gene expression segregated samples according to the IR response and time after exposure, with (56)Fe-IR showing the greatest level of gene modulation. (1)H-IR showed little differential transcript modulation. Network analysis categorized the major differentially expressed genes into cell cycle, oxidative responses, and transcriptional regulation functional groups. Transcriptional networks identified key nodes regulating expression. Validation of the signal transduction network by protein analysis and gel shift assay showed that particle IR clearly regulates a long-lived signaling mechanism for ERK1/2, p38 MAPK signaling and identified NFATc4, GATA4, STAT3, and NF-κB as regulators of the response at specific time points. These data suggest that the molecular responses and gene expression to (56)Fe-IR in cardiomyocytes are unique and long-lasting. Our study may have significant implications for the efforts of National Aeronautics and Space Administration to develop heart disease risk estimates for astronauts and for patients receiving conventional and particle RT via identification of specific HZE-IR molecular markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.