Trial report in Contraception, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 9 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors at 3 institutions in 1 country.
Bliss KaneshiroJohn A. Burns School of Medicine, University of Hawaii at Manoa, 1319 Punahou Street, Suite 824, Honolulu, HI 96826, USA. Electronic address: blissk@hawaii.edu.
Alison EdelmanOregon Health & Science University, 3181 SW Sam Jackson Park Road, UHN 50, Portland, OR 97239, USA.
Chandravanu DashMeharry Medical College, 1005 Dr. D. B. Todd Jr. Boulevard, Suite 5131, Nashville, TN 37208, USA.
Jui PandhareMeharry Medical College, 1005 Dr. D. B. Todd Jr. Boulevard, Suite 5131, Nashville, TN 37208, USA.
Faapisa M SoliRMATRIX, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Medical Education Building, Office of the Dean, 2nd Floor, Honolulu, HI 96813, USA.
Jeffrey T JensenOregon Health & Science University, 3181 SW Sam Jackson Park Road, UHN 50, Portland, OR 97239, USA.
Meharry Medical College · USOregon Health & Science University · USUniversity of Hawaiʻi at Mānoa · US
Funding
The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2M
Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
STEERING COMMITTEEU54MD008149 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI OFILI, ELIZABETH O. · 2012 to 2018
$21.1M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54RR026140 · NCRR · MEHARRY MEDICAL COLLEGE · PI MINJA-TRUPIN, CHRISTINE · 2009 to 2011
$12.9M
OHSU Women's Reproductive Health Research K12 ProgramK12HD085809 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Aaron B Caughey · 2015 to 2026
$4.0M
Methamphetamine Research Program at Meharry Medical CollegeR24DA021471 · NIDA · MEHARRY MEDICAL COLLEGE · PI RAO, UMA · 2008 to 2012
$2.0M
Role of nucleic acid structure in HIV-1 replicationR00DA024558 · NIDA · MEHARRY MEDICAL COLLEGE · PI DASH, CHANDRAVANU · 2009 to 2011
$805k
Mir-125b/p53/POX axis and HIV-1 induced neurological damageR03DA037779 · NIDA · MEHARRY MEDICAL COLLEGE · PI PANDHARE, JUI · 2014 to 2015
$289k
Cocaine downregulates anti-HIV microRNAs in CD4+ T cellsR03DA033892 · NIDA · MEHARRY MEDICAL COLLEGE · PI DASH, CHANDRAVANU · 2012 to 2013
$282k
Cocaine-Induced Epigenetic Changes in CD4+ T cells and HIV-1 ReplicationR03DA030896 · NIDA · MEHARRY MEDICAL COLLEGE · PI DASH, CHANDRAVANU · 2010 to 2011
objectivesTo describe the effect of combined oral contraceptives (COCs) on matrix metalloproteinases MMP-2 and MMP-9 activity and compare MMP activity in women taking a COC with or without doxycycline. STUDY
designSubjects (n=20) underwent endometrial biopsies (1) in the late luteal phase of a baseline cycle prior to initiating COCs, (2) on days 19-21 while taking COCs in a standard 28-day cycle (7-day hormone-free interval) and (3) on days 26-28 while taking active COCs continuously for a 28-day cycle. During the continuous COC cycle, they were randomized to receive daily subantimicrobial dose doxycycline 40mg or placebo.
resultsCompared to baseline, COC treatment increased MMP-2 (p<.001) and MMP-9 (p<.001). MMP activity was lower in subjects taking a COC with doxycycline compared to those receiving placebo although only significantly lower for MMP-2 latent form (p=.002).
conclusionsUnscheduled bleeding with COCs may be the result of increased endometrial MMPs. Sample size limitations prevent us from determining how doxycycline affects MMP activity in COC users.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Effect of oral contraceptives and doxycycline on endometrial MMP-2 and MMP-9 activity. · full record | OpenQuestion