ArticleRevista brasileira de hematologia e hemoterapia
Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases.
Article in Revista brasileira de hematologia e hemoterapia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 4 citations in OpenAlex.
- Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome.Haematologica · 2018Article
- Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.Haematologica · 2018Article
- Monoclonal B-cell lymphocytosis.Revista brasileira de hematologia e hemoterapiaArticle
- Concomitant monoclonal B-cell lymphocytosis (MBL) and CD5Hematology, transfusion and cell therapyArticle
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3 authors at 1 institution in 1 country.
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Abstract
backgroundMonoclonal B-cell lymphocytosis is classified as 'high-count or clinical' monoclonal B-cell lymphocytosis and 'low-count or population' monoclonal B-cell lymphocytosis. Previously, 167 first-degree relatives pertaining to sporadic (non-familial) chronic lymphocytic leukemia families were studied and the presence of seven monoclonal B-cell lymphocytosis individuals was reported.
objectiveThe aim of this report is to describe the outcomes of five of the original monoclonal B-cell lymphocytosis individuals.
methodsFlow cytometry analysis was performed on mononuclear cells previously isolated from peripheral blood samples. A strategy of sequential gating designed to identify the population of CD19(+)/CD5(+) B-lymphocytes was used and, subsequently, the monoclonal B-cell lymphocytosis cells were characterized by the CD20(weak)/CD79b(weak/negative) phenotype.
resultsThe monoclonal B-cell lymphocytosis clone showed consistent stability over time with little variations in size. After a median follow-up of 7.6 years, none of the five monoclonal B-cell lymphocytosis individuals progressed to chronic lymphocytic leukemia or other B-cell lymphoproliferative disease.
conclusionsThe data of this study suggest that chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis detected in the context of sporadic chronic lymphocytic leukemia families is not prone to clinical evolution and could be just a sign of immune senescence.
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