Evidence map›Paper›PMID 26408330›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Can the Risk of Lymph Node Metastases Be Gauged in Endoscopically Resected Submucosal Esophageal Adenocarcinomas? A Multi-Center Study.

Joshua A Boys, Stephanie G Worrell, Parakrama Chandrasoma, John G Vallone, Dipen M Maru, Lizhi Zhang, Shanda H Blackmon, Karen J Dickinson, Christy M Dunst, Wayne L Hofstetter and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Guideline
  2. Guideline
  3. Article
  4. Review
  5. Article
  6. Article
  7. State-of-the-art imaging in oesophago-gastric cancer.The British journal of radiology · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Endoscopic or Surgical Resection for Gastro-Esophageal Cancer.Deutsches Arzteblatt international · 2018
    Review
  17. Article
  18. Article
  19. Current Concepts in Treatment of Barrett's Esophagus With and Without Dysplasia.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017
    Review
  20. Oesophageal cancer.Nature reviews. Disease primers · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Joshua A BoysDepartment of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA, 90033, USA.
Stephanie G WorrellDepartment of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA, 90033, USA.
Parakrama ChandrasomaDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
John G ValloneDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Dipen M MaruDepartment of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Lizhi ZhangDepartment of Pathology, Mayo Clinic, Rochester, MN, USA.
Shanda H BlackmonDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Karen J DickinsonDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Christy M DunstDepartment of Surgery, Oregon Clinic, Portland, OR, USA.
Wayne L HofstetterDepartment of Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Michael J LadaDepartment of Surgery, University of Rochester, New York, NY, USA.
Brian E LouieDepartment of Surgery, Swedish Cancer Institute, Seattle, WA, USA.
Daniela MolenaDepartment of Surgery, Johns Hopkins University, Baltimore, MD, USA.
Thomas J WatsonDepartment of Surgery, University of Rochester, New York, NY, USA.
Steven R DeMeesterDepartment of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA, 90033, USA. steven.demeester@med.usc.edu.
University of Southern California · USMayo Clinic in Arizona · USThe University of Texas MD Anderson Cancer Center · USUniversity of Rochester · USJohns Hopkins University · USOregon Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoscopic resection (ER) allows for local therapy of superficial esophageal cancers. Factors reported to be associated with an increased risk of lymph node metastases in patients with adenocarcinoma are poor differentiation, lymphovascular invasion (LVI), and submucosal invasion >500 μ. The aim of this study was to determine whether depth of invasion and tumor characteristics in an ER specimen can be used to gauge the risk of lymph node metastases in patients with superficial esophageal adenocarcinoma. Patients from seven US centers that had ER of an adenocarcinoma followed by an esophagectomy were identified. The ER pathology slides were rereviewed by three experienced GI pathologists for depth of invasion, presence of LVI, and tumor differentiation. The findings from the ER specimen were correlated with the presence and number of lymph node metastases in the final esophagectomy specimen. There were 19 T1a and 23 T1b tumors. A median of 24 nodes were resected per patient. None of the T1a tumors had involved lymph nodes despite the presence of LVI in 5% and poor differentiation in 21% of patients. In contrast, 26% of T1b tumors had involved nodes. None of the four patients with submucosal invasion ≤500 μ, no LVI, and no poor differentiation had involved nodes. However, with an increasing number of risk factors, the likelihood of involved lymph nodes increased, reaching 50% when all three factors were present. Endoscopic therapy appears appropriate for intramucosal tumors and may be an option for low-risk T1b tumors. Esophagectomy is preferred for patients with submucosal invasion and one or more risk factors.

Indexed as

EsophagoscopyAdenocarcinomaEsophageal NeoplasmsEsophagectomyHumansLymphatic MetastasisLymph NodesNeoplasm InvasivenessRetrospective StudiesRisk FactorsBarrett’s esophagusEndoscopic resectionEsophageal adenocarcinomaEsophagectomy

Identifiers

PMID26408330
OpenAlexW2162096543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.