Evidence map›Paper›PMID 26408273›Full record

Trial reportCirculation2015

Sulodexide for the Prevention of Recurrent Venous Thromboembolism: The Sulodexide in Secondary Prevention of Recurrent Deep Vein Thrombosis (SURVET) Study: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.

Giuseppe M Andreozzi, Angelo A Bignamini, Giovanni Davì, Gualtiero Palareti, Jiří Matuška, Martin Holý, Katarzyna Pawlaczyk-Gabriel, Andrej Džupina, German Y Sokurenko, Yury P Didenko and 4 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  11. Anticoagulation Management Post Pulmonary Embolism.Methodist DeBakey cardiovascular journal · 2024
    Review
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  13. Article
  14. Article
  15. Albumin, oral contraceptives, and venous thromboembolism risk in astronauts.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
  16. Review
  17. [Clinical analysis of head and neck malignant tumor patients with postoperative venous thromboembolism].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Article
  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Giuseppe M AndreozziFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.). gm.andreozzi@gmail.com.
Angelo A BignaminiFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Giovanni DavìFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Gualtiero PalaretiFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Jiří MatuškaFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Martin HolýFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Katarzyna Pawlaczyk-GabrielFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Andrej DžupinaFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
German Y SokurenkoFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Yury P DidenkoFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Laurentia D AndreiFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Gianfranco LessianiFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
Adriana VisonàFrom Angiology Unit, University Hospital, Padua, Italy (G.M.A.); School of Specialization in Hospital Pharmacy, Department of Pharmaceutical Sciences, University of Milan, Italy (A.A.B.); Department of Medicine and Aging, "G. D'Annunzio" University, Chieti, Italy (G.D., G.L.); Cardiovascular Diseases, University of Bologna, Italy (G.P.); Angiologická Ambulance, Hodonín, Czech Republic (J.M.); Nemocnice České Budějovice-Interní Oddělení, České Budějovice, Czech Republic (M.H.); Department of Hypertensiology, Angiology and Internal Diseases, Medical University, Poznań, Poland (K.P.-G.); ALIAN s.r.o., Bardejov, Slovakia (A.D.); Federal State Institute, Nikiforov Russian Center of Emergency and Radiation Medicine, St. Petersburg, Russia (G.Y.S.); St. Petersburg State Medical Institution, City Multidisciplinary Hospital No. 2, Russia (Y.P.D.); Spitalul Clinic Judetean de Urgenta, Braşov, Romania (L.D.A.); and Angiology Unit, Hospital of Castelfranco Veneto, Italy (A.V.).
SURVET Study Investigators
University of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with a first episode of unprovoked venous thromboembolism have a high risk of recurrence after discontinuation of anticoagulant therapy. Extending anticoagulation reduces the risk of recurrence but is associated with increased bleeding. Sulodexide, a glycosaminoglycan, exerts antithrombotic and profibrinolytic actions with a low bleeding risk when administered orally, but its benefit for preventing recurrent venous thromboembolism is not well known. METHODS AND

resultsIn this multicenter, double-blind study, 615 patients with first-ever unprovoked venous thromboembolism who had completed 3 to 12 months of oral anticoagulant treatment were randomly assigned to sulodexide 500 lipasemic units twice daily or placebo for 2 years, in addition to elastic stockings. The primary efficacy outcome was recurrence of venous thromboembolism. Major or clinically relevant bleeding was the primary safety outcome. Venous thromboembolism recurred in 15 of the 307 patients who received sulodexide and in 30 of the 308 patients who received placebo (hazard ratio, 0.49; 95% confidence interval [CI], 0.27-0.92; P=0.02). The analysis in which lost to follow-up was assigned to failure yielded a risk ratio among treated versus control subjects of 0.54 (95% confidence interval, 0.35-0.85; P=0.009). No major bleeding episodes occurred; 2 patients in each treatment group had a clinically relevant bleeding episode. Adverse events were similar in the 2 groups.

conclusionSulodexide given after discontinuation of anticoagulant treatment reduced the risk of recurrence in patients with unprovoked venous thromboembolism, with no apparent increase of bleeding risk. CLINICAL

trial registrationURL: https://www.clinicaltrialsregister.eu/. Identifier: EudraCT number 2009-016923-77.

Indexed as

AdultAgedAnticoagulantsDouble-Blind MethodDrug Administration ScheduleFemaleFollow-Up StudiesGlycosaminoglycansHumansMaleMiddle AgedRecurrenceSecondary PreventionVenous ThromboembolismAnticoagulantsglucuronyl glucosamine glycan sulfateGlycosaminoglycansglycosaminoglycansrandomized controlled trialrecurrencevenous thromboembolism

Identifiers

PMID26408273
PMCPMC4643750
OpenAlexW2179304182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.