Evidence map›Paper›PMID 26408071›Full record

ReviewNeuroscience and biobehavioral reviews2015

The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled studies in humans and laboratory animals.

Philip Kamilar-Britt, Gillinder Bedi

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03752918 (The Effects of MDMA on Prefrontal and Amygdala Activation in Posttraumatic Stress Disorder), which is not on this map. Cited by 86 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 4 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03752918 phase1withdrawnnot on this mapstarted 2024, after this paper: background citation

The Effects of MDMA on Prefrontal and Amygdala Activation in Posttraumatic Stress Disorder

TypeinterventionalSponsorYale UniversityRan2024 to 2028Enrolled0ConditionsPost Traumatic Stress DisorderArmsMDMA, Niacin
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 4 syntheses or guidelines pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  7. MDMA enhances positive affective responses to social feedback.Journal of psychopharmacology (Oxford, England) · 2024
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  12. Detection of acute 3,4-methylenedioxymethamphetamine (MDMA) effects across protocols using automated natural language processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Trial
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  14. Effects of MDMA on attention to positive social cues and pleasantness of affective touch.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Philip Kamilar-BrittDivision on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, MC 120, New York, NY 10032, United States. Electronic address: kabritt@nyspi.columbia.edu.
Gillinder BediDivision on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, MC 120, New York, NY 10032, United States. Electronic address: gb2326@columbia.edu.
Columbia University · USNew York State Psychiatric Institute

Funding

Neurobehavioral Mechanisms of Decisions to Smoke Marijuana and Cocaine in HumansK23DA034877 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BEDI, GILLINDER I. · 2013 to 2017
$930k
Effects of MDMA ("ecstasy") and THC on Social ProcessingR03DA029679 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BEDI, GILLINDER I. · 2011 to 2011
$247k
NIDA NIH HHS DA029679NIDA NIH HHS DA034877NIDA NIH HHS K23 DA034877NIDA NIH HHS R03 DA029679
6 · The paper itself

Abstract

Users of ±3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') report prosocial effects such as sociability and empathy. Supporting these apparently unique social effects, data from controlled laboratory studies indicate that MDMA alters social feelings, information processing, and behavior in humans, and social behavior in rodents. Here, we review this growing body of evidence. In rodents, MDMA increases passive prosocial behavior (adjacent lying) and social reward while decreasing aggression, effects that may involve serotonin 1A receptor mediated oxytocin release interacting with vasopressin receptor 1A. In humans, MDMA increases plasma oxytocin and produces feelings of social affiliation. It decreases identification of negative facial expressions (cognitive empathy) and blunts responses to social rejection, while enhancing responses to others' positive emotions (emotional empathy) and increasing social approach. Thus, consistent with drug folklore, laboratory administration of MDMA robustly alters social processing in humans and increases social approach in humans and animals. Effects are consistent with increased sociability, with mixed evidence about enhanced empathy. These neurobiologically-complex prosocial effects likely motivate recreational ecstasy use.

Indexed as

Interpersonal RelationsSocial BehaviorAnimalsHumansN-Methyl-3,4-methylenedioxyamphetamineN-Methyl-3,4-methylenedioxyamphetamineEcstasyEmpathyMDMAMollyProsocialSociabilitySocial rewardSocial threat

Identifiers

PMID26408071
PMCPMC4678620
OpenAlexW1810864195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.