ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2015
Factors contributing to the increasing placebo response in antidepressant trials.
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Placebo and nocebo effects of pharmacotherapy for obsessive-compulsive related disorders: a systematic review and meta-analysis.Acta neuropsychiatrica · 2026Pooled it
- The temporal trend of placebo response in migraine prevention from 1990 to 2021: a systematic literature review and meta-analysis with regression.The journal of headache and pain · 2023Pooled it
- Treatment Response of Add-On Esketamine Nasal Spray in Resistant Major Depression in Relation to Add-On Second-Generation Antipsychotic Treatment.The international journal of neuropsychopharmacology · 2020Pooled it
- New Antidepressant Development in the Treatment of Depression.Advances in experimental medicine and biology · 2026Review
- Task-aligned outcome learning in psychiatry: reducing endpoint dilution.Frontiers in psychiatry · 2026Article
- Seventy Years of Antipsychotic Development: A Critical Review.Biomedicines · 2023Review
- A Meta-Analysis of the Antidepressant Responses in Pivotal Trials on Esketamine Nasal Spray and Atypical Antipsychotics.Neuropsychiatric disease and treatment · 2023Article
- Placebo Effect in Obsessive-Compulsive Disorder (OCD). Placebo Response and Placebo Responders in OCD: The Trend Over Time.Current neuropharmacology · 2019Review
- News from WPA Scientific Sections.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
- Has the rising placebo response impacted antidepressant clinical trial outcome? Data from the US Food and Drug Administration 1987-2013.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
- WPA Scientific Sections: update on the activities.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2016Article
- Using Artificial Intelligence-based Methods to Address the Placebo Response in Clinical Trials.Innovations in clinical neuroscienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.