Evidence map›Paper›PMID 26407684›Full record

ArticleEuropean journal of clinical pharmacology2015

Potentially inappropriate prescribing and adverse drug reactions in the elderly: a population-based study.

Khedidja Hedna, Katja M Hakkarainen, Hanna Gyllensten, Anna K Jönsson, Max Petzold, Staffan Hägg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 7 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 7 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Potentially inappropriate end-of-life care and its association with relatives' well-being: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  13. Age-dependent differences in anaphylaxis: elderly population.Current opinion in allergy and clinical immunology · 2025
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Khedidja HednaDivision of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. khedidja.hedna@liu.se.
Katja M HakkarainenNordic School of Public Health NHV, Gothenburg, Sweden.
Hanna GyllenstenNordic School of Public Health NHV, Gothenburg, Sweden.
Anna K JönssonDepartment of Clinical Pharmacology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Max PetzoldCentre for Applied Biostatistics, University of Gothenburg, Gothenburg, Sweden.
Staffan HäggDivision of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Linköping University · SENordic School of Public Health · SERegion Jönköpings län · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePotentially inappropriate prescriptions (PIPs) criteria are widely used for evaluating the quality of prescribing in elderly. However, there is limited evidence on their association with adverse drug reactions (ADRs) across healthcare settings. The study aimed to determine the prevalence of PIPs, defined by the Screening Tool of Older Persons' potentially inappropriate Prescriptions (STOPP) criteria, in the Swedish elderly general population and to investigate the association between PIPs and occurrence of ADRs.

methodPersons ≥65 years old were identified from a random sample of 5025 adults drawn from the Swedish Total Population Register. A retrospective cohort study was conducted among 813 elderly with healthcare encounters in primary and specialised healthcare settings during a 3-month period in 2008. PIPs were identified from the Swedish Prescribed Drug Register, medical records and health administrative data. ADRs were independently identified by expert reviewers in a stepwise manner using the Howard criteria. Multivariable logistic regression examined the association between PIPs and ADRs.

resultsOverall, 374 (46.0 %) persons had ≥1 PIPs and 159 (19.5 %) experienced ≥1 ADRs during the study period. In total, 29.8 % of all ADRs was considered caused by PIPs. Persons prescribed with PIPs had more than twofold increased odds of experiencing ADRs (OR 2.47; 95 % CI 1.65-3.69). PIPs were considered the cause of 60 % of ADRs affecting the vascular system, 50 % of ADRs affecting the nervous system and 62.5 % of ADRs resulting in falls.

conclusionPIPs are common among the Swedish elderly and are associated with increased odds of experiencing ADRs. Thus, interventions to decrease PIPs may contribute to preventing ADRs, in particular ADRs associated with nervous and vascular disorders and falls.

Indexed as

Accidental FallsAgedAged, 80 and overCohort StudiesDrug-Related Side Effects and Adverse ReactionsFemaleHumansInappropriate PrescribingLogistic ModelsMaleNervous System DiseasesPractice Patterns, Physicians'PrevalencePrimary Health CareRegistriesRetrospective StudiesAdverse drug reactionsElderlyInappropriate prescribingMedical recordsRegistriesRetrospective study

Identifiers

PMID26407684
PMCPMC4643104
OpenAlexW2165057233

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.