ArticleJournal of clinical periodontology2015
Lipid-lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS).
Article in Journal of clinical periodontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent.BMJ open diabetes research & care · 2021Pooled it
- Nitrate reduction by salivary bacteria, glucose metabolism, and lifestyle.Journal of oral microbiology · 2025Article
- Multi-fluid, multi-omics signatures of insulin resistance and incident type 2 diabetes among Puerto Rican adults.Frontiers in endocrinology · 2025Article
- Article
- Saliva, Plasma, and Multifluid Metabolomic Signatures of Periodontal Disease, Type 2 Diabetes Progression, and Markers of Glycemia and Dyslipidemia Among Puerto Rican Adults With Overweight and Obesity.Journal of the American Heart Association · 2024Article
- Multidisciplinary approach combining food metabolomics and epidemiology identifies meglutol as an important bioactive metabolite in tempe, an Indonesian fermented food.Food chemistry · 2024Article
- Systemic Inflammation, Endothelial Function, and Risk of Periodontitis in Overweight/Obese Adults.Biomedicines · 2023Article
- Hispanic adults with type 2 diabetes mellitus using lipid-lowering agents have better periodontal health than non-users.Therapeutic advances in chronic disease · 2023Article
- Longitudinal Association between Periodontitis and the Risk of Hypertension.International journal of dentistry · 2023Article
- Comparison of oral human papilloma virus detection methods among Hispanic adults.Clinical and experimental dental research · 2022Article
- Impact of Impaired Glucose Metabolism on Periodontitis Progression over Three Years.Dentistry journal · 2022Article
- The relationship between inflammatory dietary pattern and incidence of periodontitis.The British journal of nutrition · 2021Article
- Over-the-counter mouthwash use, nitric oxide and hypertension risk.Blood pressure · 2020Observational
- Longitudinal association between adiposity and inter-arm blood pressure difference.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Utility of point-of-care vs reference laboratory testing for the evaluation of glucose levels.Diabetic medicine : a journal of the British Diabetic Association · 2019Article
- Association of marijuana use with oral HPV infection and periodontitis among Hispanic adults: Implications for oral cancer prevention.Journal of periodontology · 2018Article
- Insulin resistance predicts the risk of gingival/periodontal inflammation.Journal of periodontology · 2018Article
- Over-the-counter mouthwash use and risk of pre-diabetes/diabetes.Nitric oxide : biology and chemistry · 2017Article
- Validation of two point-of-care tests against standard lab measures of NO in saliva and in serum.Nitric oxide : biology and chemistry · 2017Article
- Cross-sectional associations of impaired glucose metabolism measures with bleeding on probing and periodontitis.Journal of clinical periodontology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
unlabelledThe effects of lipid-lowering agents (LLA) on reducing systemic and oral inflammation have not been evaluated.
objectiveTo assess the association of LLA use with high-sensitivity C-reactive protein (hs-CRP) and oral inflammation.
designCross-sectional analysis using baseline data from 1300 overweight/obese participants aged 40-65 years, recruited for the ongoing San Juan Overweight Adults Longitudinal Study. Serum hs-CRP was measured by ELISA, gingival/periodontal inflammation was evaluated as bleeding upon probing (BOP), and LLA was self-reported. Separate logistic models were performed for systemic and oral inflammation.
resultsIn all, 24% participants reported history of dyslipidaemia, of which, 50.3% self-reported LLA use. Sixty percent of the participants had elevated hs-CRP (>3 mg/dl) and 50% had high BOP (defined as at or above the median: 21%). After adjusting for age, gender, smoking, HDL-C, physical activity, diabetes, blood pressure medications, and percent body fat composition, LLA users had significantly lower odds of elevated hs-CRP compared to LLA non-users (OR = 0.58; 95% CI: 0.39-0.85). After adjusting for age, gender, smoking status, educational level, mean plaque index and percent body fat, LLA users had significantly lower odds of high BOP compared to LLA non-users (OR = 0.62; 95% CI: 0.42-0.91).
conclusionsLipid-lowering agents may reduce both systemic and oral inflammatory responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.