Evidence map›Paper›PMID 26407665›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2015

The physiological concentration of ferrous iron (II) alters the inhibitory effect of hydrogen peroxide on CD45, LAR and PTP1B phosphatases.

Alicja Kuban-Jankowska, Magdalena Gorska, Lukasz Jaremko, Mariusz Jaremko, Jack A Tuszynski, Michal Wozniak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The metal face of protein tyrosine phosphatase 1B.Coordination chemistry reviews · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Alicja Kuban-JankowskaDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland. alicjakuban@gumed.edu.pl.
Magdalena GorskaDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Lukasz JaremkoMax Planck Institute for Biophysical Chemistry and German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Mariusz JaremkoDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Jack A TuszynskiDepartment of Physics, University of Alberta, Edmonton, Canada.
Michal WozniakDepartment of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.
Gdańsk Medical University · PLGerman Center for Neurodegenerative Diseases · DEUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen peroxide is an important regulator of protein tyrosine phosphatase activity via reversible oxidation. However, the role of iron in this reaction has not been yet elucidated. Here we compare the influence of hydrogen peroxide and the ferrous iron (reagent for Fenton reaction) on the enzymatic activity of recombinant CD45, LAR, PTP1B phosphatases and cellular CD45 in Jurkat cells. The obtained results show that ferrous iron (II) is potent inhibitor of CD45, LAR and PTP1B, but the inhibitory effect is concentration dependent. We found that the higher concentrations of ferrous iron (II) increase the inactivation of CD45, LAR and PTP1B phosphatase caused by hydrogen peroxide, but the addition of the physiological concentration (500 nM) of ferrous iron (II) has even a slightly preventive effect on the phosphatase activity against hydrogen peroxide.

Indexed as

Dose-Response Relationship, DrugDrug InteractionsFerrous CompoundsGene Expression RegulationHumansHydrogen PeroxideJurkat CellsLeukocyte Common AntigensProtein Tyrosine Phosphatase, Non-Receptor Type 1Receptor-Like Protein Tyrosine Phosphatases, Class 2Signal TransductionFerrous Compoundsferrous sulfateHydrogen PeroxideLeukocyte Common AntigensProtein Tyrosine Phosphatase, Non-Receptor Type 1PTPN1 protein, humanPTPRC protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 2CD45Ferrous ironHydrogen peroxideLARPTP1B

Identifiers

PMID26407665
PMCPMC4635172
OpenAlexW2184465782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.