ReviewFrontiers in neuroendocrinology2015
Developmental specification of metabolic circuitry.
Review in Frontiers in neuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Article
- Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior.iScience · 2025Article
- AgRP neurons mediate activity-dependent development of oxytocin connectivity and autonomic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming.Frontiers in endocrinology · 2022Review
- Hypothalamic Neurochemical Changes in Long-Term Recovered Bilateral Subdiaphragmatic Vagotomized Rats.Frontiers in behavioral neuroscience · 2022Article
- Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus.eLife · 2020Article
- Feeding circuit development and early-life influences on future feeding behaviour.Nature reviews. Neuroscience · 2018Review
- Development of the hypothalamus: conservation, modification and innovation.Development (Cambridge, England) · 2017Review
- Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis.Molecular metabolism · 2017Article
- Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei.Neural development · 2016Article
- Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice.Molecular brain · 2016Article
- Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia.Molecular metabolism · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The hypothalamus contains a core circuitry that communicates with the brainstem and spinal cord to regulate energy balance. Because metabolic phenotype is influenced by environmental variables during perinatal development, it is important to understand how these neural pathways form in order to identify key signaling pathways that are responsible for metabolic programming. Recent progress in defining gene expression events that direct early patterning and cellular specification of the hypothalamus, as well as advances in our understanding of hormonal control of central neuroendocrine pathways, suggest several key regulatory nodes that may represent targets for metabolic programming of brain structure and function. This review focuses on components of central circuitry known to regulate various aspects of energy balance and summarizes what is known about their developmental neurobiology within the context of metabolic programming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.